GHS Classification Result

Chemical Name：O,O-dimethyl phthalimidomethyl S-phosphorodithioate
CAS：732-11-6

Result：
ID: 1250
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of experimental data, though "Flammable"
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat oral LD50 values (121.3 - 369mg/kg, number of data: 14) (JMPR 448 (1978)), we obtained the LD50 of 199.7mg/kg by calculation, and we classified the substance as Category 3.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Considering rabbit dermal LD50 value = 3160mg/kg (JMPR 448 (1978)), it was set as Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - The saturated concentration of this product is 6.43*10^(-4) ppm. Therefore, it is presumed that each inhalation test was performed in mist conditions. Since there is no data about steam, it cannot be classified.
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the lower one among rat inhalation LC50 (4 hours) = 0.054mg/L (RTECS (2003)) and LC50 (1 hour) = 2.76mg/L [4-hour conversion value 0.69mg/L] (HSDB (2003)), it was set as Category 2.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. There is description which indicates irritant in Priority 2 (HSDB (2003), SITTIG (4th, 2002)). But there is no specific information, Moreover, the irritation was set to "mildly" in HSDB (2003), it was thought that irritant was slight, and it was set as 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		There is description which indicates the irritation against the human eyes by Priority 2 (ICSC (J) (1997), and SITTIG (4th, 2002)), in addtion, the irritation was set to "mildly" (HSDB (2003)). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - There is the negative result of the in vivo small core test using mouse bone marrow cells (JMPR 883 (1994)), and it is classified as the out of the Category according to the technical guidelines.
6 Carcinogenicity Not classified - - - - There was the description (all are JMPR 883 (1994)) that liver adenomas (high-dose male rat) or a pituitary adenoma arises to a rat. But JMPR judged the carcinogenic negative in rat and mouse as a conclusion. Therefore, it considered as the outside of category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Although remarkable influence was not seen except that the slight skeletal abnormalities in the fetus were acknowledged in high doses in the rabbit teratogenicity studies on the of Priority 1 (JMPR 883 (1994)), some influence on reproduction ability (decline in copulation rate and fertilization rates) was seen in the two-generation examination on rats (JMPR 883 (1994)). So it was set as Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system) Warning H371: May cause damage to organs (nervous system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since in Priority 2, there is description of "a nervous systems may be affected" to humans (ICSC (J) (1997), SITTIG (4th, 2002), in addition, effect on a nervous system also in the experimental to the male rat of JMPR 448 (1979) is observed, (however, since original literature is old and the detailed experimental condition are unknown, application of a guidance value cannot be performed), it was considered as Category 2 (nervous system).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since in Priority 1 (JMPR 883 (1994)), to humans (spraying working personnel of this substance), although it is reversible, the neuromuscular dysfunction and ultrastructure defects of motor end plates are observed and moreover, in the experiment of the rat in Priority 1(JMPR 883(1994)), since the effects on the liver was observed within the limits of Category 2 of a guidance value, it was classified into Category 1 (nervous systems) and Category 2 (liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48-hour LC50=27microg/L of Crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2003).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=2.78(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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