GHS Classification Result

Chemical Name:Ammonium dichromate
CAS:7789-09-5

Result:
ID: 1254
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Although it is combustible (ICSC (J) (2005) has statement as "nonflammable"), UNRTDG is classified into 5.1 and II according to the UNRTDG No. (1439). Since 4.1 was not assigned, it was classified as out of Category.
8 Self-reactive substances and mixtures Not applicable - - - - Classified in oxidizing solids
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Not classified because of "Flash point: 190degC"(HSDB, 2003)
11 Self-heating substances and mixtures Not classified - - - - UNRTDG is classified into 5.1 and II according to the U.N. number (1439) peculiar to a substance. Since 4.2 was not attached, it carried out the outside of Category.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Category 2 Danger H272: May intensity fire; oxidizer P370+P378: In case of fire: Use ... for extinction.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P220: Keep/Store away from clothing/.../combustible materials.
P221: Take any precaution to avoid mixing with combustibles/...
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
UNRTDG No. 1439, Class: 5.1; PG II.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat oral LD50 values: 55mg/kg (male) and 48mg/kg (female), we adopted the lower value (48mg/kg) to classify the substance as Category 2.
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was set as Category 4 from rabbit dermal LD50 = 1860mg/kg (EU-RAR (2005)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 2 based on rat LC50 (4hr) = 0.2mg/L (EU-RAR (2005)) in inhalation study (mist).
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since there was description that caustic is indicated to human skin (ICSC (J), (2005)) and that produces a deep ulcers by contact to the skin (SITTIG (4th, 2002)), as well as it was classified in "C;R34 (a burned is produced)" according to the European risk phrases, it was set as Category 1A-1C. In addition, further categorizing from this data is difficult.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
There is the description that corrosiveness is shown to the human eye (ICSC(J)(2005)), critical disorder with the possibility of loss of eyesight is developed (SITTIG(4th, 2002), and HSFS(1986)), moreover, it was classified to Category 1 by the skin causticity. So it was set to Category 1.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ...
In addition to asthma may be caused by repetition or the long-term inhalation to humans (ICSC(J)(2005)), this substance is classified into "R42 (inhalation may cause sensitization)" according to the EU risk phrases. Moreover, chromium and chromium compound were classified into "the 2nd group (material considered that there is probably sensitizing to human)" in Japan Association of Industrial Health, and chromium was classified into the material with respiratory sensitization in Japanese Society of Occupational Allergy Special Committee, this product thought that it had respiratory sensitization and was set to Category 1.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
In this product, by repetition or long-term contact to human, in addition to sensitization of the skin may be carried out (ICSC(J)(2005)), there is a report of skin sensitization by occupation exposure to this product (IUCLID(2000)). Moreover, it is classified into "R43 (skin contacts may cause sensitization)" according to the EU risk phrases. Furthermore, since hexavalent chromium compound is classified into "Sh (risk of skin sensitization)" in DFG, chromium and chromium compound are classified into "the 1st group (material which has sensitizing clearly to human)" in Japan industrials society, this product was considered to have skin sensitization, and was set to Category 1.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although there is only a positive (EHC61(1988), IUCLID (2000)) in an in vitro mutagenicity test (Ames) as this product data, about the flood solubility hexavalent chromium compound, there is the mutagenicity knowledge in in vivo (NTP RoC (11th, 2005), IARC49 (1990), EU-RAR (2005)). So it is classified into Category 2. In addition, potassium dichromate (ID 262, CAS: 7778-50-9, potassium dichromate) Category 1B from a dominant fatality tests positives, and sodium dichromates (ID 260, CAS: 10588-01-9) is categoried into Category 2 from positivities, such as an in vivo small core test.
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
As a chromium compound of 6 values, it was classified into K (Chromium hexavalent(VI)compounds) by NTP (2005), group 1 (Chromium(VI)) according to IARC (1990), and A (Chromium(VI), Inhalation route) according to EPA (1986). Therefore, it was set as Category 1A.
7 Reproductive toxicity Classification not possible - - - - By ICSC (J) (2005), there is description "it is indicated by the animal studies that reproductive and developmental toxicity may be caused in people." Although the R of EU risk phrases classified that "Repr. Cat. 2; R60-61 (R60: spoils the rgenitalium R61: do damage to the fetal)". But there is no concrete data which the reproductive toxicity of this product, and it was presupposed that data is insufficient and it cannot be classified. In addition, for the reproductive toxicity of hexavalent chromium compound, refer to potassium dichromate (ID 262, CAS: 7778-50-9, and it is classified into Category 1B).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, kidney, liver) Danger H370: Causes damage to organs (respiratory system, kidney, liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
A soluble hexavalent chromium compound affects liver, the kidney, and respiratory organs in the document of Priority 1(ACGIH-TLV (2005)), and, in the document of Priority 2, "oral ingestions indicates caustic and there is condition of nausea, vomiting, abdominal pain, feeling of heat, diarrhea, and a shock/atrophy. Caustic is indicated to an airway by inhalation and there is a feeling of heat, a pharyngeal pain, a cough, inspiration, and stuffiness. Sice there is description that it may affect the kidney and liver and tissue damage may be produced" (ICSC (J) (2005), SITTIG (4th, 2002), HSFS (1986)), it was considered as Category 1(the respiratory system, kidney, liver).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, kidney, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since there was description that soluble hexavalent chromium compound may affect liver, the kidney, and respiratory organs (ACGIH-TLV(2005) the document of Priority 1), and that in human "respiratory tract and the kidney are affected, and nasal septal perforation and kidney disorder may be occured" (ICSC(J)(2005), SITTIG(4th, 2002), and HSFS(1986) the document of Priority 2), it was classified into Category 1 (the respiratory systems, kidney, liver).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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