GHS Classification Result

Chemical Name：Fentin hydroxide
CAS：76-87-9

Result：
ID: 1269
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although it is combustible (ICSC (J) 2005; HSDB, 2005), there is no test data, and it cannot be classified.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (the water solubility is obtained)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Category 3 based on SPECIES: Rat (female); ENDPOINT: LD50; VALUE: 156 mg/kg; REFERENCE SOURCE: JMPR 827 (1991), CIACD 13 (1999)
1 Acute toxicity （Dermal） Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on the lower value (127mg/kg)(from rat dermal LD50 = 1600mg/kg and rabbit dermal LD50 = 127mg/kg (JMPR 827, 1991;CICAD 13, 1999)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 2 based on rat inhalation LC50 = 0.06mg/L/4H (JMPR 827, 1991).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was slight response in tests for rabbit skin irritation (JMPR 827, 1991). But it was set as category 2 since the moderate irritation was indicated in the human epidemiological findings (CICAD 13, 1999).
3 Serious eye damage/eye irritation Category 2A-2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		From the statement that the eye of a rabbit (JMPR 827, 1991) and a guinea pig (RTECS, 2005) is stimulated strongly, and the statement that the human eye is stimulated strongly (ICSC, 2005), it was set as Category 2A-2B. In addition, the detailed categorization is difficult.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Since it was negative (CICAD 13, 1999) in guinea pig skin sensitization test (Buehler method and maximization method), an allergic reaction was not admitted in the human patch test (CICAD 13, 1999), it considered as the outside of Category.
5 Germ cell mutagenicity Not classified - - - - There is the negativity in the rat dominant fatality test, a mouse bone marrow small core test, and a Chinese hamster marrow chromosome aberration test (JMPR 827, 1991; CICAD 13, 1999), and there is the conclusion of "Triphenyl tin compound does not indicate genotoxicity" in CICAD 13 (1999) as a result of evaluation of a series of triphenyl tin compound. So it is classified as the out of the Category. In addition, although an Ames test indicates negative, the positivety is also seen in the mouse lymphoma test or the in vitro chromosome aberration test (JMPR 827, 1991). Moreover, although the positivity in an in vivo mouse peripheral blood small core test and an in vitro small core test is reported these days (RTECS, 2004). But all of the grade of the reaction were weak and dose responses was not clear in in vivo, either, the weights of hazards to humans was judged to be a not high.
6 Carcinogenicity Not classified - - - - Some tumor discoveries were acknowledged in the carcinogenic tests using mouse and rats. But the WHO experts group didn't consider them significant into, and concluded that there is no carcinogenic in triphenyl tin (CICAD 13, 1999). Moreover, the organotin compounds was set to A4 (not classified with a the human carcinogen) in ACGIH (ACGIH-TLV, 2005). Therefore, it carried out the outside of category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since influences on reproduction or generating (embryo absorption, hydrocephalus, etc.) were seen in rat or the hamster in the dose which indicates maternal toxicity (CICAD 13, 1999), it was set as Category2.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since in single time oral administrations to animals, central nervous systems condition, such as vomiting, a tremor, and a deep sleep, is observed in within the range of guidance value in Category 1 (CICAD 13, 1999), and human central nervous systems may have been affected in ICSC (2005), it was considered as Category 1 (central nervous systems). Moreover, it was considered as Category 3 (respiratory irritant) from description (ICSC, 2005) that a respiratory tracts is stimulated.
9 Specific target organ toxicity - Repeated exposure Category 1 (immune system) Danger H372: Cause damage to organs through prolonged or repeated exposure (immune system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since in a mouse and a rat, decrease of immune cell numbers and decrease in immunoglobulin concentration are observed in the guidance concentration range of Category 1(CICAD 13, 1999) and triphenyl tin compounds may affect an immune system and may impair that function (CICAD 13, 1999), it was classified into Category 1 (immune systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=7.1microg/L (water oxidization triphenyltin concentration equivalent: 7.4microg/L) of fishes (Fathead minnows) (CICAD13, 1999).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=7100 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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