GHS Classification Result

Chemical Name：fentin acetate
CAS：900-95-8

Result：
ID: 1270
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although it is flammable (there is a description that the flash point is 185 plus or minus 5 degC in PM (13th, 2003)), there is no test data, and it cannot be classified.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (insoluble in water)
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat oral LD50 values : 140mg/kg and 298mg/kg (JMPR 827, 1991), we adopted the lower value (140mg/kg) to classify the substance as Category 3.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 from rat dermal LD50 = 450mg/kg (PIM(Poisons Information Monograph) 589, 1994;RTECS, 2004;HSDB, 2003).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From rat inhalation LC50 value (male: 0.044mg/L/4H, female: 0.069mg/L/4H)(JMPR 827, 1991), the lower male data (male: 0.044mg/L/4H) was adopted, and it was set as Category 1.
2 Skin corrosion/irritation Not classified - - - - Since irritation was not indicated to skin of rabbits (CICAD 13, 1999;JMPR 827, 1991), it carried out the outside of Category.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since a strong injury was indicated and it did not recover to the eye of a rabbit (CICAD 13, 1999; JMPR 827, 1991), it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Since it was considered as the positive in guinea pig skin sensitization test (the Buehler method) (CICAD 13, 1999), it was referred to as Category 1.
5 Germ cell mutagenicity Not classified - - - - Threre is the negativity in rat and mouse dominant fatality test (JMPR 827, 1991; PIM (Poisons Information Monograph) 589 and 1994), and there is the conclusion of "Triphenyl tin compound does not indicate genotoxicity" in CICAD 13 (1999) as a result of evaluation of a series of triphenyl tin. So it is classified as the out of the Category. In addition, in the Ames test, it is considered as negative (JMPR 827, 1991). Moreover, although the positivity in an in vivo mouse peripheral blood small core test and an in vitro small core test was reported recently (RTECS, 2004), the grade of the reaction was weak. So all judged the weights of hazards to humans to be a not high.
6 Carcinogenicity Not classified - - - - The carcinogenic is not acknowledged in the carcinogenic tests using mouse (PIM (Poisons Information Monograph) 589, 1994), not considered that triphenyl tin is not carcinogenic (CICAD 13, 1999). In addition, the organotin compounds was set to A4 (not classified with a the human carcinogen) in ACGIH (ACGIH-TLV, 2005). Therefore, it carried out the outside of category.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since influences on reproduction or generating (increase in embryo absorption, reduction in the number of implantation and the number of survival fetus, hydroureter, and omphalocele) were seen in rats or rabbits at the dose which indicates maternal toxicity (JMPR 827, 1991; PIM (Poisons Information Monograph) 589, 1994), and the influence of triphenyl tin compounds on reproduction and generating was seen in laboratory animals (CICAD 13, 1999). So it was set to Categoty2.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (central nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since influence on central nervous systems, such as headache and nausea, is observed in humans (CICAD 13, 1999), moreover, although there is no data of this product itself, and the potential of respiratory irritant (ATSDR, 2005;ACGIH 7th, 2001) is indicated as an organic tin compounds, it was considered as Category 1 (central nervous system) and Category 3 (respiratory irritant).
9 Specific target organ toxicity - Repeated exposure Category 1 (immune system) Danger H372: Cause damage to organs through prolonged or repeated exposure (immune system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Since suppression of immune responses to tetanus toxoids in a guinea pig is observed in the guidance concentration range of Category 1(CICAD 13, 1999), and, triphenyl tin compounds may affect an immunity system and may impair this function (CICAD 13, 1999), it was classified into Category 1 (immune systems).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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