GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Distannoxane, hexabutyl-
CAS：56-35-9
Result：
| ID: | 1275 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Not classified | - | - | - | - | Not classified because of its flash point: 190degC(C.C.) (ICSC(J), 1998) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Uses are sterilization and antifungal agent, a ship's-bottom paint additive agent etc., and even if it contacts the air of normal temperature, it does not ignite spontaneously. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (the water solubility is obtained) |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | No data available |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Because the oral LD50 values in rats are 127-234mg/kg (CICAD 14, 1999) or 92-194mg/kg (DFGOT 1, 1991), the substance was classified as Category 3. |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 3 from rat dermal LD50 = 605mg/kg (ACGIH 7th, 2001;DFGOT 1, 1991). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Category 2 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on rat inhalation LC50 value 65mg/m3/4H (= 0.065mg/L/4H) (DFGOT 1 (1991); CICAD 14 (1999); ATSDR (2005)), it was set as Category 2. |
| 2 | Skin corrosion/irritation | Category 2 |
|
Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse. |
Since severe irritation was indicated in the Draize's examination using human and rabbit skin (RTECS, 2004) and it was considered as the powerful skin stimulativeness substance (CICAD 14, 1999), it was set as Category 2. |
| 3 | Serious eye damage/eye irritation | Category 2A |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Since severe irritation was indicated in the Draize Test using a rabbit eye (RTECS, 2004), and it was considered as the strong eye stimulativeness substance (CICAD 14, 1999; ICSC, 1998), it was set as Category 2A. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | While it was negative (CICAD 14, 1999) in guinea pig skin sensitization test ( Magnussen-Kligman method) and there were findings that allergic was not accepted in humans (ATSDR, 2005), since the contact sensitizing activity was acknowledged in the mouse in recent years, it was presupposed from (ATSDR, 2005; CICAD 14, 1999) that it cannot classify. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | It carried out the outside of Category. Based on the mouse small core test from the negative (ATSDR, 2005;CICAD 14, 1999) , and negative in the Ames test an in vitro mutagenicity test and the cell gene mutation test. So it is classified as the out of the Category. In addition, it is considered as the positive by levels of cytotoxicity concentration in the in vitro chromosome aberration test (CICAD 14, 1999), and the weak reaction occurs by part of mouse small core test. But it is synthetically estimated as negativity (ATSDR, 2005; CICAD 14, 1999). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | The endocrine systems oncogeny was slightly seen in the rat about this product. But it was negative in the mouse (CICAD 14, 1999), and classified into D (it cannot classify into human carcinogenicity) (IRIS, 2002), or I (evidence is inadequate for humans carcinogenicity evaluation) (ATSDR, 2005) according to EPA. Moreover, the organotin compounds was classified into A4 (it cannot classify into a the human carcinogens) in ACGIH. Therefore, it was carried out the outside of category according to the guideline. |
| 7 | Reproductive toxicity | Not classified | - | - | - | - | Although the slight influences on reproductive developments, such as an fetus weight fall, ossification variation, and the number fetus of one mother, were admitted. They were dosage which effect on the maternal toxicity and immune system (IRIS, 2002; CICAD 14, 1999). And since the this product was not considered to be a reproductive developmental toxicity substances (CICAD 14, 1999), it was set as the outside of Category. |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Respiratory tract irritation） |
|
Warning | H335: May cause respiratory irritation (respiratory tract irritation) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Since there was knowledge which indicates respiratory irritant to humans (CICAD 14, 1999), it was considered as Category 3 (respiratory irritant). In addition, unlike other organotin compounds, about this product, effect is not observed in a nervous systems (CICAD 14, 1999). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (immune system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (immune system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Since the key virulence trait of this product is the influence on immune systems based on the knowledge acquired by animal studies(thymus dependence immune dysfunction) (CICAD 14, 1999), and since this knowledge is accepted in the guidance value of Category 1, it was classified into Category 1 (immune system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96-hour LC50=1.5microg/L of fishes (King salmon) (EHC116, 1990). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 2% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=12100 (existing chemical substances safety inspections data)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |