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GHS Classification Result

Chemical Name：Diaminotoluene
CAS：25376-45-8

Result：


ID:	1309
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	-	-	-	-	No data available
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	It is used as an intermediary body, etc. for dyes. It was thought that it did not ignite spontaneously even if it contacts the normal temperature air, and it was defined as "out of Category".
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to solid (melting point <= 140degC) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine and chlorine.
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat oral LD50 = 270mg/kg for toluylenediamine (the composition ratio unknown) (RTECS(1997)), the substance was classified as Category 3. [Note] This substance is a general term for 2, 3- , 2, 4- , 2, 5- , 2, 6- , 3, 4- , 3, 5-diaminotoluene, and there are no findings in which the composition ratios of the substances are identified. Refer to the classification results of the most common isomers, 2,4-toluenediamine (ID167, CAS: 95-80-7) and 2,5-diaminotoluene (para-toluenediamine, ID1324, CAS: 95-70-5). For the health hazard information, the classification results for 2,4-toluenediamine (ID167, CAS: 95-80-7) are listed when necessary.
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 3 from rat dermal LD50 = 463mg/kg (RTECS (1997)) of toluylene-diamine (composition percentage unknown).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Data without. In addition, 2,4-toluenediamine (ID 167, Chemical Abstracts Service:95-80-7) is set as category 3.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	While there is a report that irritation is not caused to the eye of a rabbit with each isomer of toluenediamine (HSDB (2003)), there is one example of knowledge which accepted blepharitis with corneal opacity in humans (HSDB(2003)), since data is insufficient, it cannot classify. In addition, in 2,4-toluenediamine (ID167, CAS: 95-80-7), it is referred to as Category 2A.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Since the toluilenediamine is assumed to be the human skin sensitization substance, and 2,4-toluenediamine (ID167,CAS:95-80-7) that is one of the isomers is classified into Category 1, it was referred to as Category 1.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data. In addition, in 2,4-toluenediamine (ID 167, C AS: 95-80-7), it is considered as the outside of Category.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since substantial amount of 2,4-toluenediamine (ID 167, CAS: 95-80-7) classified into category 2 were included, it was set as category 2.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although any effect on reproduction is not found in human epidemiological study, there are several reporting reduced sperm counts (HSDB (2003)). In addition, in 2,4-toluenediamine (ID 167, CAS: 95-80-7), it has been classified as Category 2 based on the effect on reproductive potential of male animals and generation of baby animals. Thus it was similarly set as Category 2
8	Specific target organ toxicity - Single exposure	Category 1 (liver)		Danger	H370: Causes damage to organs (liver)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Since a certain kind of diamine including toluidine amines indicates severe hepatotoxicity to laboratory animals (HSDB (2003)), in addition 2, 4-toluenediamine (ID 167, CAS:95-80-7) has hepatotoxicity to humans, it was considered as Category 1 (liver). In addition, it isconsidered as Category 1 (liver, a central nervous system, blood systems) and Category 3 (respiratory irritant) in 2,4-toluenediamine (ID 167, CAS: 95-80-7).
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Since a certain kind of diamine including toluidine amine shows severe hepatotoxicity in laboratory animals (HSDB (2003)), in addition, since the effect on the liver of 2 and 4-toluenediamine (ID 167, Chemical Abstracts Service:95-80-7) was observed in the range of the guidance being equivalent to Category 1 in laboratory animals, it was classified into Category 1 (liver). In addition, it is classified into Category 1 (liver, kidney) and Category 2 (blood systems,spleen,testes) in 2 and 4-toluenediamine (ID 167, Chemical Abstracts Service:95-80-7).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 2 from 48-hour EC50=4.3mg/L of Crustacea (Daphnia magna) (IUCLID, 2000).
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 2, since acute toxicity was Category 2, and supposed not rapidly degrading (BIOWIN), though supposed less bio-accumulative (log Kow=0.16(PHYSPROP Database, 2005)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）