Chemical Name:Butyric acid, 2-hydroxy-4-(methylthio)-
CAS:583-91-5
ID: | 1336 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified | - | - | - | - | Since the flash point was 121 degC (C. C.) (CHRIS-Chemical Hazard Response Information System, U.S.DOT/U.S.Coast Guard, 1999), it was classified as out Category. |
7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
9 | Pyrophoric liquids | Not classified | - | - | - | - | The firing points is 121 degC (C. C.) (CHRIS-Chemical Hazard Response Information System, U.S.DOT/U.S.Coast Guard, 1999), and even if it contacts the normal temperature air, it does not ignite spontaneously. |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen chemically bonded only to carbon and hydrogen (but not to other elements). |
14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Category 5 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 3170mg/kg; (IUCLID, 2000), 3478mg/kg; REFERENCE SOURCE: RTECS (1997) |
1 | Acute toxicity (Dermal) | Classification not possible (Category 5 or Not classified) | - | Warning | H313: May be harmful in contact with skin | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | From rabbit LD50 value >2000mg/kg (IUCLID, 2000) of the dermal administration test, it cannot be classified (Category 5 or outside of Category). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
It was set to category 2 from the description that mild irritation (slight;4 hr) is indicated in the rabbit skin or a middle degree stimulus (Moderate; 24 hr) is indicated in vitro test (IUCLID, 2000). | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
It was set as Category 1 from description which causes caustic (Corrosive) to the rabbit eye (IUCLID, 2000). | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Not classified | - | - | - | - | Since skin sensitization was not observed in the repetitive application on the human skin (218 patients) (IUCLID, 2000), it carried out the outside of Category. |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | It is only a negative report (IUCLID, 2000) of an Ames test, and it cannot be classified because of insufficient data. |
6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 72-hour ErC50=87mg/L of algae (Selenastrum) (IUCLID, 2000). |
11 | Hazardous to the aquatic environment (Long-term) | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Classified into Category 3, since acute toxicity was Category 3 and rapid degradability is unknown, though supposed less bio-accumulative (log Kow=-0.07 (PHYSPROP Database, 2005)). |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |