GHS Classification Result

Chemical Name:BHC or HCH
CAS:608-73-1

Result:
ID: 1348
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J) (1998))
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 1998)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (1998))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and the chlorine is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat oral LD50 = 100mg/kg (PIM257 (2001), HSDB (2003) and RTECS (2004)) and 2428mg/kg (ATSDR (2005)) , we adopted the lowest value to classify the substance as Category 3. [Note] 1,2,3,4,5,6-hexachlorocyclohexane has several stereoisomers (alpha-; beta-; gamma-; delta-isomers, etc.), but this ID for the health hazardswas investigated and classified as CAS: 608-73-1(isomer mixture) . Also refer to the classification results of 1,2,3,4,5,6- hexachlorocyclohexane [Linden] (ID612, CAS: 58-89-9) which is the gamma-isomer.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 3 from rat dermal LD50 = 900mg/kg (PIM257 (2001), RTECS (2004)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 3 Danger H331: Toxic if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P311: Call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as category 3 base on rat inhalation LC50 (4hr) = 0.69mg/L (RTECS (2004)). In addition, considering the saturated concentration (about 0.01mg/L) computed from this substance's steam pressure (0.1Pa at 25degC), it was presumed that the experiment was conducted in dust and mists conditions.
2 Skin corrosion/irritation Classification not possible - - - - Insufficient data available
3 Serious eye damage/eye irritation Classification not possible - - - - Insufficient data available.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - There is the description(ICSC(J)(1998) that dermatitis may be caused by repetition or the long-term skin contact to the human, it is unknown whether SITTIG (4th, 2002)) is caused by an allergic reaction, and data is insufficient and it cannot classify. In addition, also refer to 1, 2, 3, 4, 5, 6-hexachlorocyclohexane [Linden] (ID 612, and CAS:58-89-9).
5 Germ cell mutagenicity Not classified - - - - There is the negative result of the dominant fatality test using a mouse, and the negative result of the in vivo chromosome aberration test using mouse bone marrow cells (IARC, Suppl.7 (1987), ATSDR (2005), PIM257 (2001)), and it is classified as the out of the Category. In addition, although there is also positive knowledge in mice dominant fatality tests, it is considered as suspicious (IARC, Suppl.7 (1987)). Moreover, Ames test negative (DFGOT vol.5 (1993)) and an in vitro chromosome aberration test positivity (ATSDR (2005), HSDB (2003)) are reported by the in vitro mutagenicity test. In addition, Linden (gamma-body) which is one of the isomer of the quality of this substance is considered as the outside of Category (refer to Linden (ID 612, CAS: 58-89-9)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since it is classified into 2B (IARC Suppl.7 (1987)), B-2 (as industrial hexachlorocyclohexane) according to EPA (IRIS (2003)), and R (as Linden and other hexachlorocyclohexane isomeric form) according to NTP (NTP RoC (11th, 2005)), it was set as category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although no effect was observed in three-generation reproduction studies and teratogenicity tests using rats (ATSDR (2005)), increased embryo absorption and decreased survival fetus were observed (but not teratogenicity) in reproduction and development toxicity tests using mice (ATSDR (2005), HSDB (2003)) and, in ICSC (J) (1998), there was a descriprion that animal tests showed the potential of toxic effects on human reproduction. Thus, it was set as Category 2. In addition, Linden (gamma-body), one of the isomeric forms of this substance, is set as "out of Category" (see Linden (ID 612, CAS: 58-89-9)).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It was considered as Category 1 (nervous system) and Category 3 (respiratory irritant) based on the description that it affects human central nervous system in the document of Priority 1 and 2 (nausea, vomiting, muscle spasm, tremor etc.) (PIM257 (2001), DFGOT vol.5 (1993), ICSC (J) (1998), HSDB (2003)), and it stimulates a nose, a throat, and a respiratory tract (HSDB (2003), SITTIG (4th, 2002)). Also refer to Linden (gamma body) (ID 612, CAS:58-89-9) which is one of the isomer of this product.
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system), Category 2 (liver, kidney) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (central nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since symptoms of nausea and tremor in addition to the face and limb paresthesias, headache, and giddiness were observed in the humans who inhaled this product (PIM257 (2001) the document of Priority 1), symptoms such as vomiting, tremor, and paralysis of the hind limbs were observed with the dose being equivalent to Category 1of a guidance value in a rat (ATSDR (2005)), and the effect was observed in liver (cell hypertrophy, centrilobular degeneration, etc.) and kidney (a glomerular degeneration, the tubular necrosis etc. ) with the dose being equivalent to Category 2 of a guidance value (ATSDR (2005), DFGOT vol.5 (1993)), it was classified into Category 1 (central nervous systems) and Category 2 (liver, kidney). Also refer to Linden (gamma object) which is one of the isomers of this product (ID 612, CAS:58-89-9) .
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=0.34microg/L of Crustacea (Pink shrimp) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=893 (existing chemical substances safety inspections data)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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