GHS Classification Result

Chemical Name：2-Naphthol
CAS：135-19-3

Result：
ID: 1349
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though "Flammble" (ICSC(J), 1995)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - There is a description that the flash point is 153 degC (CLOSED CUP) in HSDB (2006), and it was thought that there was no spontaneous combustibility even if it contacted the normal temperature air. Thus, it was defined as "out of Category".
11 Self-heating substances and mixtures Not classified - - - - It was widely used as an industrial materials, and it was considered that there is no self-febrility (dyes, preservative, etc.), and they were carried out the outside of Category.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and the oxygen is chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Category 4 based on SPECIES: Rat(female and male); ENDPOINT: LD50; VALUE: 1320mg/kg; REFERENCE SOURCE: SIDS (2006), IUCLID (2000)
1 Acute toxicity （Dermal） Not classified - - - - It was as the outside of Category from LD50 value >10000mg/kg (SIDS, 2006) of the dermal administration test using rats and rabbits.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		It was set as Category 4 based on LC50 value of an inhalation administration test using female male rats, that is 2.2mg/L/4H (2200mg/m3/4H) (SIDS, 2006; IUCLID, 2000).
2 Skin corrosion/irritation Not classified - - - - It carried out the outside of Category from description which does not stimulate a rabbit eye (SIDS, 2006;IUCLID, 2000).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		From description which causes serious stimulation to the human eye (ICSC(J), 2005) and the rabbit eye (SIDS, 2006; IUCLID, 2000), it is set as Category 2A.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		From the description that sensitization of the skin is carried out (SIDS, 2006; IUCLID, 2000; ICSC(J), 2005) and sensitization of the guinea pig skin is carried out (SIDS, 2006; IUCLID, 2000), Skin sensitization is considered as Category 1.
5 Germ cell mutagenicity Not classified - - - - There is the negativity by the in vivo mutagenicity test (micronucleus test which uses mouse bone marrow cells) (SIDS, 2006), and it is classified as the out of the Category. In addition, the reverse mutation test (Ames test) using bacteria is also negative (SIDS, 2006; IUCLID, 2000).
6 Carcinogenicity Classification not possible - - - - There is only a knowledge that the carcinogenesis promoter activity in the female mouse skin was not acknowledged by the limited study(SIDS, 2006;IUCLID, 2000), and data is insufficient. So it cannot be classified.
7 Reproductive toxicity Not classified - - - - Based on the statement that there was no effect on reproduction toxicity and malformation in single-generation studies using both male and female rats (SIDS, 2006), it was set as "out of Category".
8 Specific target organ toxicity - Single exposure Category 2 (kidney, blood) Warning H371: May cause damage to organs (kidney, blood) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 2 (kidney, blood) based on the description of nephropathy, hemolytic anemia (HSDB, 2006) by human exposure, and hematuria (RTECS, 2006) by inhalation of human lowest toxic dose (0.5mg/m3).
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney), Category 2 (blood) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (kidney)
H373: May cause damage to organs through prolonged or repeated exposure (blood) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified into Category 1 (kidney) and Category 2 (blood) based on description which affected change of a renal function in humans (SIDS, 2006;ICSC(J), 2005), and blood in humans (ICSC (J), 2005). Although there is a description "an eye may be affected and lens opacities may be occured"(ICSC (J) and (2005)), this was based on old data, and since the affect on an eye was not described (SIDS (2006) of Priority 1 document), it was not included in a classification.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96-hour LC50=2500microg/L of Crustacea (Brown shrimp) (AQUIRE, 2003).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since rapidly degrading (BOD: 68.4% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=2.7 (PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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