GHS Classification Result

Chemical Name:Chlordimeform
CAS:6164-98-3

Result:
ID: 1356
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140degC) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and the chlorine is chemically bonded only to carbon (but not to other elements).
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 = 192mg/kg calculated by the oral LD50 data : 250, 340, 123, 301, 178, 265 and 460mg/kg (EHC199 (1998)), 150, 220 and 170mg/kg (JMPR206(1972)), the substance was classified as Category 3.
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 3 from the value (LD50 = 263mg/kg) calculated based on rat dermal LD50 = 640, 337, 263mg/kg (EHC199 (1998)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
It was set as Category 4 based on rat inhalation LC50 (1hr) = 14.7mg/L (4-hour equivalent 4.35mg/L) (JMPR206 (1972)). In addition, the saturated concentration of this product is about 0.47ppm (3.7mg/m3) (20degC), and it is presumed that the inhalation study was done in mist conditions.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was set as Category 3 from description that skin of rabbits is stimulated slightly (EHC199 (1998)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
It is set as Category 2B from statement which stimulates eye of rabbit slightly (slight erythemas and conjunctival chemosis, and all are recovered within seven days)(EHC199 (1998)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Although a skin eruption is seen by the workers handling this substance (EHC199(1998), JMPR322(1975)), it cannot check that it is caused in the allergic reaction, and cannot classify according to the shortage of data.
5 Germ cell mutagenicity Not classified - - - - There was a negative result of the reciprocal translocation test and a dominant fatality test using a mouse, the chromosome aberration test using a mouse spermatocyte, and a mouse spot test (EHC199(1998);JMPR719 (1985)). So it considered as the outside of Category. And it is classified as the out of the Category. In addition, it is reported that a Ames test is negativity (EHC199 (1998)).
6 Carcinogenicity Not classified - - - - Based on being classificationed into "Group 3 (it being unable to classify about the carcinogenic to humans)." in IARC (IARC Suppl.7 (1987)), it carried out the outside of category by the technical indicator. In addition, about this product, "it is supposed that there is now only a less persuasive proof on correlation between exposure to a chlordimeform and human bladder cancer generating." (EHC199 (1998) (J)). Moreover, it is classified into Carc.cat 3 (GHS Category about [ 2 ]) according to the EU classification.
7 Reproductive toxicity Not classified - - - - In rat three-generation administration tests and teratogenicity tests, and rabbit teratogenicity tests, only slight effects (decreased feeding & care, reduced weight of babies at weaning, ossification disorder of newborn's sternum, etc.) were seen at maternal toxicity dose (all of them in EHC199 (1998)). Thus, it was set as "out of category".
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, urinary bladder, kidney, cardiovascular system), Category 2 (blood) Danger
Warning
H370: Causes damage to organs (nervous system, urinary bladder, kidney, cardiovascular system)
H371: May cause damage to organs (blood)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
Since there is description that in the document of Priority 1, "it causes a feeling of fatigue, nausea, and an appetite fall in acute poisoning, and causes lethargy, cyanosis, harndrang, cystitis, a cardiovascular actions (change of tachycardia, bradycardia and ECG), a coma, and a shock in severe cases."(EHC199 (1998)). Inaddition, the condition of the acute hemorrhagic cystitis accompanied by abdominal pain, dysuria and hematuria were observed to the workers who were engaged in washing of the tank used for the transport of this product (EHC199 (1998)). So it was considered as Category 1 (a nervous system, a bladder, the kidney, cardiovascular system). Moreover, it was considered as Category 2 (blood) from description (ICSC (J) (1994)) "it affects blood and methemoglobin is generated."
9 Specific target organ toxicity - Repeated exposure Category 1 (urinary bladder, kidney, cardiovascular system, skin) Danger H372: Cause damage to organs through prolonged or repeated exposure (urinary bladder, kidney, cardiovascular system, skin) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since there is a report that humans in occupational and chronical exposure to this product were affected with hematuria, cystitis, dysuria, pruritus and a rash of the skin (exposure to the skin), etc. in addition to a part of above-mentioned acute symproms ((EHC199(1998), JMPR322(1975), JMPR719(1985)) the document of Priority 1), it was classified into Category 1 (a bladder, the kidney, cardiovascular systems,skin).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=1mg/L of fishes (Bluegill) (EHC199, 1998).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=2.89(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information