Chemical Name:N'-(4-chloro-o-tolyl)-N,N-dimethylformamidine monohydrochloride
CAS:19750-95-9
ID: | 1357 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible | - | - | - | - | No data available |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods suitable for solid materials are not established. In addition, ICSC (J) (1994) have the description "it corrodes many metals under presence of water." |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 | Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LD50 = 268mg/kg calculated by the rat oral LD50 data : 305, 325 and 330mg/kg (EHC199 (1998)), 265 and 355mg/kg (JMPR206 (1972)) and 225mg/kg (RTECS (2003)), the substance was classified as Category 3. * Also refer to the information on N'-(2-Methyl-4-chlorophenyl)-N,N-dimethylfolmamizine (ID1357, CAS: 6164-98-3), which is the base compound of this substance. | |
1 | Acute toxicity (Dermal) | Category 5 | - | Warning | H313: May be harmful in contact with skin | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | It was set as Category 5 from rat dermal LD50 = 4g/kg (RTECS (2003)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | There is only data with rat inhalation LC50 (1hr) value >5.8mg/L (JMPR206 (1972)) (4-hour equivalent, in the case of steam >2.9mg/L, and in the case of mist/particulate >1.45mg/L). Since the data is insufficient, it cannot be classified. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | There is only a data with rat inhalation LC50 (1hr) value: >5.8mg/L (JMPR206 (1972)) (4-hour equivalent, in the case of steam: >2.9mg/L, and in case of mist and particulate: >1.45mg/L), and it cannot be classified since data is insufficient. |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | It was set as Category 3 from description that the rabbit skin is stimulated slightly (EHC199 (1998)). |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Since there was description that "Mild" irritation was indicated as a result of the Standard Draize Test using a rabbit eye (RTECS (2003)), it was set as Category 2B. |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | Although there is description "dermatitis may be caused if the skin is contacted over repetition or a long period of time" to humans (ICSC(J)(1994)), it could not check with the thing resulting from an allergic reactions, but it was presupposed that data is insufficient and it cannot classify. In addition, it is supposed with the base compound (ID 1356, Chemical Abstracts Service:6164-98-3) of the this substance that it cannot classify. |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | The reciprocal translocation test and a dominant fatality test using a mouse, the chromosome aberration test using a mouse spermatocyte, a mouse spot test, a Chinese hamster bone marrow micronucleus and chromosome aberration test shows the negative result (EHC199 (1998)). So it is classified as the out of the Category. In addition, it is reported that an Ames test and the mouse lymphoma test are negativity (EHC199 (1998)). |
6 | Carcinogenicity | Category 2 | Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There was a report that malignant hemangioendothelioma arose in subcutaneous tissue, the back peritoneum, and internal organs (the kidney, liver, spleen) in mice by feed-mix administration (EHC199 (1998), JMPR431 (1978)), it was set as category 2. In addition, the base compound (ID 1356, Chemical Abstracts Service:6164-98-3) of this substance is carried out the outside of category since it is classified into "Group 3" in IARC. | |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data. In addition, in the base compound of this substance (ID 1356, CAS: 6164-98-3), it is defined as "out of category". |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system, blood, urinary bladder, kidney) | Warning | H371: May cause damage to organs (nervous system, blood, urinary bladder, kidney) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Since there was description (ICSC (J) (1994)), in the document of Priority 2, "this substance affects a nervous system and blood, produces a dysfunction, and may generate methemoglobin to humans. This substance may affect a bladder and the kidney and may produce the inflammation of a bladder, and hematuria", it was considered as Category 2 (nervous systems, blood, bladders, kidney). In addition, also refer to the information on the base compound of this substance (ID 1356, CAS: 6164-98-3). | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (skin) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (skin) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified into Category 2 (skin) based on description of "dermatitis may be occured in repeated or long-term dermal exposure." (ICSC (J), (1994)). In addition, although the formation of methemoglobin was acknowledged as a result of the feeding administration during 24 months to rats of this product (JMPR467 (1979)), the toxic effect data is not found. Also refer to the information on the base compound (ID 1356, CAS:6164-98-3) of this product. | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible | - | - | - | - | Insufficient data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |