Chemical Name：N-[2-[1-(4-Chlorophenyl)-1H-pyrazole-3-yloxymethyl]phenyl]-N-methoxycarbamic acid methyl ester
CAS：175013-18-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Not classified because of SPECIES: Rat; ENDPOINT: LD50; >5000 mg/kg; REFERENCE SOURCE: Agricultural Chemicals Registration Data
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	It was set as the outside of Category. Based on rat LD50 >2000mg/kg in the dermal administration test and that there was no death (Agricultural Chemical Registration Data).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 3		Danger	H331: Toxic if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 3 based on rat LC50 = 0.58mg/L. (Agricultural Chemical Registration Data) that was a result of the inhalation study done by melting to a solvent in order to make it a diameter which can be inhaled.
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	It was set to category 3 according to the technological direction based on the statement that the average value of the marks of erythema was 1.8 and the average value of edema were 0.4 as a result of the skin stimulus examination using rabbits (Agricultural Chemical Registration Data).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	In the eye irritation tests using a rabbit, each average marks of the cornea and the iris in application 24 to 72 hours were 0.0, and ophthalmic grade are 1.7 in redness and 0.6 in the dropsy. And it wes completely reversible in eight days (Agricultural Chemical Registration Data). So it was set as the outside of Category according to the technical indicator.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	Based on the description (Agricultural Chemical Registration Data) that it is negative, it carried out the outside of Category by the skin sensitivity test using a guinea pig.
5	Germ cell mutagenicity	Not classified	-	-	-	-	There is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, and there is the description that it is negative in the somatic cell in vivo mutagenicity test (small core test using mouse erythrocytes) (Agricultural Chemical Registration Data). So it is classified as the out of the Category.
6	Carcinogenicity	Not classified	-	-	-	-	It carried out the outside of category based on the statement (Agricultural Chemical Registration Data) that there was no generating of the tumor relevant to the dose by the carcinogenicity tests using rats and mice.
7	Reproductive toxicity	Not classified	-	-	-	-	Although weight reduction of the dam animal was seen in the two-generation reproduction study using rats and the birth weight reduction of baby animals and the growth retardation resulting from the mother's weight reduction were seen, there was no effect on reproductive potential. Although there was the growth retardation in baby animals reflecting the low weight at birth, the animals grew normally with progress of time. So it was judged that there was no effect on and through lactation. Teratogenicity was not seen in the teratogenicity test of the rat/rabbit (Agricultural Chemical Registration Data). Based on the above information, it was set as "out of category".
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	It was considered as Category 1 (nerve systems) based on the description (Agricultural Chemical Registration Data ), in a rat, at the dose within the range of guidance value in Category 1 (more than 0.31mg/L), closed eyelids, respiratory distress, panting, a breath sound, assuagement, squatting position, the irregularity of breathing, increased and intermittent, blood-like nasal discharge, eye closures, apathetic, escape, contamination of piloerection and hair were observed.
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, duodenum, liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (blood system, duodenum, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	An important common toxic phenomena of a rat, a mouse, and a dog is anemia. It was classified into Category 2 (blood systems, duodenum, liver) based on the description that duodenal mucosa hyperplasia, diffuse decreased fatty change of liver, hepatocyte hypertrophy, splenic histiocytoses, sinus extension increases, and increased extramedullary hematopoiesis ewere observed in a rat, with the given dose (more than 34.7 mg/kg) of guidance value within the limits of Category 2 (Agricultural Chemical Registration Data).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=0.019mg/L of fishes (Carp) (Agricultural Chemical Registration Data, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, and rapid degradability is unknown, though less bioaccumulative (BCF494 (Agricultural Chemical Registration Data, 1999)).