GHS Classification Result

Chemical Name:trizinc diphosphide
CAS:1314-84-7

Result:
ID: 1377
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Nonflammable (ICSC (J), 2001). (However, since it will decompose on contact with water, damp air or acid, and produce flammable fumes, such as phosphine, cautions are needed.)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 2001)
11 Self-heating substances and mixtures Not classified - - - - Not combustible (ICSC(J) (2001))
12 Substances and mixtures which, in contact with water, emit flammable gases Category 1 Danger H260: In contact with water releases flammable gases which may ignite spontaneously P231+P232: Handle under inert gas. Protect from moisture.
P335+P334: Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P370+P378: In case of fire: Use ... for extinction.
P402+P404: Store in a dry place. Store in a closed container.
P223: Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Category 1 UNRTDG No. 1714, Class: 4.3, PG I
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Inorganic compounds containing no oxygen and halogen.
15 Organic peroxides Not applicable - - - - Inorganic compound
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LD50 : 42.6mg/kg (99.9% purity), 43.8mg/kg (94% purity), 54mg/kg (87% purity) and 55.5mg/kg (83% purity) (Agricultural Chemical Registration Data, 1992), we adopted the LD 50 value with 99.9% purity to classify the substance as Category 2.
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was set as Category 4 based on LD50 value of female rat (LD50 = 1123mg/kg) of the dermal administration test. ( Rat LD50 = 1123mg/kg (female) and 1414mg/kg (male)(Agricultural Chemical Registration Data, 1992)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - Since four cases show the very slight redness 1 hour after eliminating coated gauze in the skin irritation test (3% zinc phosphites granules) using rabbits, but they were disappeared 24 hours afterward (Agricultural Chemical Registration Data, 1992), it carried out the outside of category.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
By the eye irritation tests (3% zinc phosphites granules) using a rabbit, inflammation of the iris, moderate stimulus to conjunctiva was accepted, and muddiness of the cornea of diffusion was accepted by one example in the ocular-mucous membrane of non-washing group. Although slowdown of the gloss of the cornea usually seen was accepted in 3 examples at 1 hour after medication, it became normal at 72 hours or at 7 days (Agricultural Chemical Registration Data). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - By the skin sensitization study (3% zinc phosphites granules) in the Buehler method using a guinea pig, from the result that skin sensitization is negative (Agricultural Chemical Registration Data, 1992), it carried out the outside of Category.
5 Germ cell mutagenicity Classification not possible - - - - There is no test results of in vivo, and there is the negative result in in vitro gene mutagenicity test (Ames test) (Agricultural Chemical Registration Data, 1992). So it cannot be classified because of insufficient data.
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Classification not possible - - - - No data available
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system) Danger H370: Causes damage to organs (central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Since it acts on the central nervous system by the hydrogen phosphide generated from zinc phosphide in the gastric as biological activity of zinc phosphide granules 3% and the lethal action was indicated (Agricultural Chemical Registration Data, 1992), it was considered as Category 1 (central nervous systems). In addition, although there is description that a mildest positive histologic changes was observed in the kidney and lungs in rat acute oral toxicity test (Agricultural Chemical Registration Data, 1992), data is insufficient only in these data.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since the small necrotic foci of liver was observed with high occurrence in male administration groups with 100 ppm (equivalent for estimate of 15mg/kg/day) in the three-month repeated oral feeding administration examination of a mouse, (Agricultural Chemical Registration Data, 1992), it was classified into Category 2 (liver) from comparison with a guidance value.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Classification not possible due to lack of data


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information