GHS Classification Result

Chemical Name：2,3-epoxypropyl o-tolyl ether
CAS：2210-79-9

Result：
ID: 1
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - There is no data of this substance and classification is not possible. In addition, although there is LD50 value 4,000 mg/kg of the oral administration test employing a rat (RTECS (1999)), since the test substance is a product of Epoxide No.8, and is estimated to be Cresyl glycidyl ether (CAS number 26447-14-3), it is not adopted. Also refer to Cresyl glycidyl ether (CAS number 26447-14-3) for health hazard.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a liquid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified in Category 2 based on the description, "being stimulative" (ICSC (2005)). EU-Annex I shows Xi; R38, which corresponds to the GHS Category 2. There is, however, a description, "slight irritation" (IUCLID (2000)), in the study using rabbits based on the OECD Gideline 404 and comforming to GLP. The data corresponding to this substance among the information of CAS No. 26447-14-3 were used for the data of IUCLID (2000).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		From the description of "Mild irritation" (ICSC (2005)), it was classified into Category 2B. However, it is described as "slight stimulation" (IUCLID (2000)) in the test employing a rabbit in conformity to OECD Guideline 405 and GLP. The data corresponding to this substance in the information on the CAS number 26447-14-3 was adopted for the data of IUCLID (2000).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		It was classified as Category 1 from description of possible sensitization in the test conforming to the OECD Guidelines 406 and GLP employing guinea pig (IUCLID (2000)). EU-Annex I is R43 and is equivalent to the GHS Category 1. The data corresponding to this substance in the information on the CAS number 26447-14-3 was adopted for the data of IUCLID (2000).
5 Germ cell mutagenicity Not classified - - - - From the results of negative in the reverse mutation test of the compulsive oral administration employing the mouse in vivo (body fluid analysis test), negative in the chromosomal mutation examination (micronucleus test), and negative in dermal administration dominant lethal test employing the mouse (EPA OPPT, TSCATS Low Detail Report), it was classified into "Not classified". In addition, in vitro studies, the result is positive in back mutation assays with salmonella (NTP DB (Access on Dec.2007)) and in host mediated tests with mice and bacteria, and there is a weak effect in irregular DNA synthesis inhibition studies with human white blood cells (EPA OPPT, TSCATS Low Detail Report). EU-Annex I is Muta.Cat.3; R68 and is equivalent to the GHS Category 2. Cat.3 of the EU classification is assumed to be defined after consideration of the epoxy structure and the mutagenicity caused by the structure.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it was indicated as slight degree (mildly) Respiratory tract irritation by ICSC (2005), it was classified into Category 3 (Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations

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