GHS Classification Result

Chemical Name:2-butanone oxime
CAS:96-29-7

Result:
ID: 3
Classifier: Ministry of Economy, Trade and Industry (METI)
Year Classified: FY2007
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases (including chemically unstable gases) - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
LD50 value of the oral administration test employing a rat was classified into Category 4 from LD50 value = 1,440 mg/kg obtained by application of the formula based on 2,528 mg/kg, 2,326 mg/kg, 3,700 mg/kg (IUCLID (2000)), and 930 mg/kg (IUCLID (2000), RTECS (2006)).
1 Acute toxicity (Dermal) Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
From LD50 value of the dermal administration test employing a rabbit being 1,000-2,000 mg/kg (IUCLID (2000)), 1,000 mg/kg which is a lower limit LD50 value was adopted and classified into Category 3. EU-Annex I is R21 and is equivalent to the GHS Category 3-4.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a liquid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Since it was written that there was no mortality in twelve rats even if they were exposed in saturated steam at 20degC (0.076 mg/L) for 8 hours (4-hour equivalent 0.152 mg/L) (IUCLID (2000)), LC50 value is >0.152 mg/L.. Since the vapor standard value of Category 1 is 0.5 mg/L, classification is not possible.
1 Acute toxicity (Inhalation: Dusts and mists) Not classified - - - - Saturated vapor pressure level (20degC) is 0.076 mg/L. LC50 value of the inhalation administration test employing rats is 20 mg/L / 4hr (IUCLID (2000)). Since the standard value of Category 4 is 0.05 mg/L according to the mist standard, it was classified into "Not classified".
2 Skin corrosion/irritation Classification not possible - - - - In the studies of rabbits described in IIUCLID (2000) "irritating" and "not irritating" coexist regarding EC division. The study result stating "slightly irritating" by the Draize test is classified as "being stimulative" in EC division. When Study from 1978, TSCATS fiche OTS0524679, the primary information source for this study was checked, there were no details of exposure time etc., described. Moreover, although several 24hr-exposure tests are listed in IUCLID and all of the EC classifications are "irritating", classification is not possible since details of the tests are unknown. In addition, it was not classified into R34 and R38 in EU Annex I.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
There are descriptions of "highly irritation (1989)" (IUCLID (2000)) and of "severe irritation (1987)" (RTECS (2006)) against rabbits, it was classified into Category 1. EU-Annex I is R41 and is equivalent to the GHS Category 1.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was classified into "Category 1" from a description of Sh in Germany-MAK of ACGIH-TLV and based on "possible sensitizing properties in the maximization test complied with GLP with guinea pig" (IUCLID (2000)). In addition, EU-Annex1: R43 is equivalent to the GHS Category 1.
5 Germ cell mutagenicity Not classified - - - - As for in vivo mutagenicity tests using a somatic, the micronucleus tests employing mouse peripheral blood was negative (NTP DB (Access on Dec.2007)), and chromosome aberration test employing rats bone marrow cell and the micronucleus tests which uses mouse peripheral blood and bone marrow cells were negative (IUCLID (2000)), therefore, it was classified into "Not classified". And as for in vitro studies, although very weak genetic toxicity was observed in vitro reverse mutation test using bacteria under specific conditions, it was negative in SCE test using CHO cultured cells and chromosome aberration test (NTP DB (Access on Dec.2007)), and in the reverse mutation test using bacteria and chromosome aberration test using CHO cultured cells (Health, Labor and Welfare Ministry reports (Access on Dec.2007)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since it was classified into Cat. 3; R40 according to EU-Annex I, it was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - While maternal toxicity can be found at the level even less than 10mg/kg in the 2 generation reproductive toxicity study via oral administration using rats conforming to GLP, no effect was caused in F1 and F2 generations even at the level of 200mg/kg. On the other hand, in the developmental toxicity study conforming to GLP 3 cases of miscarriage have been confirmed at the dose amount (40mg/kg) where 8 out of 18 parent animals died (IUCLID (2000)). It is not appropriate to ignore reproductive toxicity, judging the fetal toxicity (miscarriage) as the secondary effect, even when the dose amount 40mg/kg is a low dose level where parent animals die. Therefore, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - There is a description of "symptom of drowsiness" at 50 mg/L/4hr in the inhalation administration test employing rats. (RTECS (2006)). However, when the data of LC50 value 20 mg/L in the inhalation administration test employing rats (IUCLID (2000)) is taken into consideration, 50 mg/L/4hr is equivalent to the lethal concentration. Therefore, it is unsuitable to classify in the paragraph of specified target organ toxicity (single exposure), and classification is not possible. However, when LC50 value 20 mg/L is judged to be irrelevant after scrutinizing the primary literature of IUCLID (Federal register USA (1986) 51, 220, 41430-41432. methylethyl ketonoxime), RTECS' "Symptoms Of Sleepiness" may be adopted and it may be classified as Category 3 (Narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 1 (hematopoietic system, liver, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (hematopoietic system, liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Since in 28-day repeated oral administration toxicity test in rats, "there were increase in reticulocyte rate, effects on lien (congestion, increased extramedullary haemopoeisis, and increase in granule of hemosiderin), etc. in the group of males and females more than 20 mg/kg, and increase in platelet count, decrease in the number of red blood cells, drop in hematocrit, and decrease in hemoglobin content, etc. in the group of females more than 20 mg/kg (Ministry of Health, Labour and Welfare reports (Access on Dec. 2007)), it was classified into Category 1 (blood system). Furthermore, since in the oral administration simple reproductive toxicity study, "the enhance of the accruals number or the level of congestion, pigmentation of lien, extramedullary hematopoiesis, liver carbohydrate deposit, pigmentation of Kupffer cells, congestion, and brown pigmentations of kidney in the administered group of males and females more than 10 mg/kg" are seen, it is added Category 1 (liver, kidney) and to be Category 1 (blood system, liver, kidney).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) - - - - - -
11 Hazardous to the aquatic environment (Long-term) - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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