GHS Classification Result

Chemical Name：2-(2-methoxyethoxy)ethanol
CAS：111-77-3

Result：
ID: 4
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Each data of LD50 value >5,500-9,210 mg/kg and LD50 value 6,900 mg/kg (EU-RAR (2000)) of the oral administration test employing a rat is "Not classified". It was classified into "Not classified" from 6,900 mg/kg of the lower value which can be identified.
1 Acute toxicity （Dermal） Not classified - - - - Each of LD50 value 6,540 mg/kg, 20,400 mg/kg, and 9,284 mg/kg (EU-RAR (2000)) of the dermal administration test employing a rabbits is "Not classified". The calculation value from these data is 5,125 mg/kg, and is smaller than that of the minimum value of the data (6,540 mg/kg). Therefore, it was classified into "Not classified" from minimum value of data of 6,540 mg/kg.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a liquid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Due to insufficient data, classification is not possible. In addition, there is no mortality at 8- hour inhalation administration of saturated vapor pressure level employing rats (4-hour equivalent: 2.5 mg/L) (EU-RAR (2000)). Although 2.5 mg/L does not correspond to Category 2 since it is the level within the standard value of Category 3, the suitability of Category 3-4 cannot be judged.
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - Since LC50 value of the inhalation administration test employing rats is >200 mg/L (EU-RAR (2000)), it was classified into "Not classified".
2 Skin corrosion/irritation Not classified - - - - Since no irritation was acknowledged at the time of observation 5 hours, and 1, 2, and 3 days after application in the test in which 0.5 mL was adopted to the shaved skin of rabbits (EU-RAR (2000)), it was classified into "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - Since it has been described that, in OECD guideline studies employing rabbits, there was no irritation (EU-RAR (2000)), it was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Not classified - - - - It was classified into "Not classified" since it had no sensitizing potential in the maximization test employing guinea pig conforming to OECD and EEC guideline (EU-RAR (2000)).
5 Germ cell mutagenicity Classification not possible - - - - Although there was a negative data in the reverse mutation test employing the bacterial by OECD 471 (EU-RAR (2000)) and in the chromosome aberration test employing the culture cell by OECD 473, classification is not possible because there is no in vivo data.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since increase in deformation of internal organs of baby animals such as disorders in the aortic arch and ventricular septal defects as major developments(2.4%) and increase in the development rate of pyelectasis at the dose level where toxicity does not develop in parent animals in the developmental toxicity study via oral administration using rats have been recognized according to EU RAR(2000), it was classified in Category 1B. EU Annex 1 is, however, Repr. Cat.3,;R63, corresponds to GHS Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The activity fall and the stagger walk are looked in the dermal administration test employing a rabbit. Moreover, coma and decrease of activity were looked as a toxic phenomena in the inhalation exposure test employing a rabbit (EU-RAR (2000)), therefore, it classified into Category 3 (Narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 90 days dermal administration test employing guinea pig, the fatty degeneration of the liver which increases dose-dependently has been observed. (0/7, 2/6, 6/6, 6/6, respectively at doses of 0, 40, 200, and 1,000 mg/kg/day) (EU-RAR (2000)). Since 40 mg/kg/day is the concentration within the range of the guidance value of Category 2, it was classified into Category 2 (liver). In addition, in 6 week oral and 90 days vapor inhalation administration test employing rats, affections were not seen in neighborhood of the guidance value upper limit of Category 2 (EU-RAR (2000)).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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