GHS Classification Result

Chemical Name：bis(2-methoxyethyl)ether
CAS：111-96-6

Result：
ID: 6
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. From a description of LD50 value of 4,760 mg/kg (CICAD 41 (2002)) in the oral administration test employing rats, it was classified into Category 5.
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a liquid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Due to insufficient data, classification is not possible. In addition, there was no mortality even if inhalation administration of the saturated vapor (about 10 mg/L) was carries out to rats for 7 hours (4-hour equivalent: 13.2 mg/L) (CICAD 41 (2002)). Although 13.2 mg/L does not correspond to Category 3 since it is the level within the standard value of Category 4, the suitability of Category 4 cannot be judged.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Although slight irritation after 24 hours and crack after 72 hours were obsereved in the occlusive patch test with rabbits by FDA guideline, the details are unknown (CICAD 41 (2002)). Since "mild skin irritation" was described in ICSC (2004), it was classified into Category 3.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Although, in FDA guideline studies employing rabbits, the slight irritation is found after 24 hours, the details are unknown (CICAD 41 (2002)). Since ICSC (2004) has described as "It has mild eye irritation," it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Not classified - - - - Since the in vivo mutagenicity test employing a somatic (chromosome aberration test employing a rats bone marrow cell) was negative, and the in vitro mutagenicity test (two or more Ames examinations) was negative (CICAD 41 (2002)), it classified into "Not classified". In addition, the positive reaction (early embryonic lethality) was seen in the dominant lethal tests, however, it is thought that it is based on the fall of the fertility (breeding ability) instead of a dominant lethality (CICAD 41 (2002)).
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since effects on the growth and survival rate of fetuses and deformation have been observed at the concentration level not affecting parent animals(NTP DB (Access on Jan 2008)) in the teratogenicity study via oral administration using mice and injury lesions of spermatocytes at the pachytene stage and circular spermatids have been identified in the inhalation exposure testinhalation exposure test using rata (6 hours/day, 5days /week, 2 weeks),(CICAD 41("")), it was classified in Category 1B. Mofreover, resorption and deformation in fetuses have been observed at the concentration level where effects are observed in the body weight, weight increase and uterus weight of mother animals in the teratogenicity study via oral administration using rabbits(NTP DB (Access on Jan 2998)). EU-Annex I is Cat.2, R60-61, corresponding to GHS Category 1B.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation)
H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The symptoms, such as the state of being restless, have been observed in the inhalation administration test and oral administration test employing rats (CICAD 41 (2002)). Moreover, PATTY (5th, 2005) has indicated that Ethylene glycol and their derivatives have reversible actions to central nervous system. This becomes the supporting evidence of the classification of Diethylene glycol ethers including this substance. Moreover, ICSC (2004) has a description of "It has mild respiratory tract irritation." As mentioned above, it was classified into Category 3 (Narcotic effects, Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (thymus, adrenal gland) Warning H373: May cause damage to organs through prolonged or repeated exposure (thymus, adrenal gland) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		When inhalation administration of the 600 ppm (90 days corresponding value: 140 ppm) was applied to the rats for three weeks, changes of the blood parameter were not observed but the thymic atrophy and the congestion of the adrenal gland were observed (CICAD 41 (2002)), thus, it was classified into Category 2 (thymus, adrenal gland).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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