GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1,2,4-triazole
CAS：288-88-0
Result：
| ID: | 14 |
| Classifier: | Ministry of Economy, Trade and Industry （METI） |
| Year Classified: | FY2007 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | - | - | - | - | - | - |
| 2 | Flammable gases （including chemically unstable gases） | - | - | - | - | - | - |
| 3 | Aerosols | - | - | - | - | - | - |
| 4 | Oxidizing gases | - | - | - | - | - | - |
| 5 | Gases under pressure | - | - | - | - | - | - |
| 6 | Flammable liquids | - | - | - | - | - | - |
| 7 | Flammable solids | - | - | - | - | - | - |
| 8 | Self-reactive substances and mixtures | - | - | - | - | - | - |
| 9 | Pyrophoric liquids | - | - | - | - | - | - |
| 10 | Pyrophoric solids | - | - | - | - | - | - |
| 11 | Self-heating substances and mixtures | - | - | - | - | - | - |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | - | - | - | - | - | - |
| 13 | Oxidizing liquids | - | - | - | - | - | - |
| 14 | Oxidizing solids | - | - | - | - | - | - |
| 15 | Organic peroxides | - | - | - | - | - | - |
| 16 | Corrosive to metals | - | - | - | - | - | - |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on LD50 value 1,683 mg/kg obtained by application of the formula to rat LD50 value (1,650, 1,648, and 1,750 mg/kg) in IUCLID (2000), it is classified into Category 4. In addition, EU Annex I is R22 and is equivalent to the GHS Category 3 to 4. |
| 1 | Acute toxicity （Dermal） | Category 5 | - | Warning | H313: May be harmful in contact with skin | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on 3,129 mg/kg of lower value among LD50 values of the rat in IUCLID (2000) (male: 4,200 mg/kg, female: 3,129 mg/kg), it is classified into Category 5. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since it was a solid by the definition of GHS, it was classified into "Not applicable". |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Although "no irritation" is described for a 7 day observation study with 24 hour application to rabbits of unknown number in IUCLID (2000), classification is not possible, because information is not of Priority1. |
| 3 | Serious eye damage/eye irritation | Category 2 |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Although the number of animals is unknown, there is a description in IUCLID (2000) that 50 mg was applied to a rabbit, "high irritant" in the seven days observational study. Although this is thought to be equivalent to Category 2A or Category 2B, since it is inadequate as a basis of fine classification, it is classified into Category 2. In addition, EU Annex I is R36 and is equivalent to the GHS Category 2. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Although there was the negative result in IUCLID (2000) in the in vitro Ames test, it classification is not possible because there is no in vivo examination result. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since it is reported in IUCLID(2000) of Priority 2 that the loss of fetuses by resorption and deformation (cleft palates and peromelia) increased at the dose level (200mg/kg/day) where symptoms other than body weight reduction among parent animals have not been reported in the developmental toxicity study using rats, it is classified in Category 2. Incidentally, thorough reviewing was not carried out, because the primary document was a study report prepared by the manufacturing company(Bayer (1988)). In addition,EU Annex I is Cat3;F63,corresponding to GHS Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In Priority 2 in IUCLID (2000), there is a report of liver degeneration in a 13-week study in rats with a dosage of 167 mg/kg/day. Similarly, in Priority 2 in RTECS (1997), there is a report of abnormalities in the central nervous system and the kidneys in a 13-week study in rats with a dosage of 364 mg/kg/day. These dosages, however, exceeded the guidance values for Category 2 of 100 mg/kg/day, and since no studies were conducted using dosages within the range of the guidance values, it was classified into "Classification not possible" because of insufficient data. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | - | - | - | - | - | - |
| 11 | Hazardous to the aquatic environment （Long-term） | - | - | - | - | - | - |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |