GHS Classification Result

Chemical Name：1,2-dimethoxyethane
CAS：110-71-4

Result：
ID: 17
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. It was classified into Category 5 from LD50 value 2,525 mg/kg (PATTY (5th, 2005)) of the oral administration test employing a mouse.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. From a description of LDLo value of 2,000 mg/kg (RTECS (2006)) in the dermal administration test employing rabbits, it was classified into Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a liquid by the definition of GHS, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - The LDLo value of 6-hour inhalation administration test employing rats is 63 mg/L (4-hour equivalent: 77 mg/L (20,933 ppm)) (RTECS (2006)). Since saturated vapor pressure level (20degC) is 81,000 ppm (299 mg/L), it is over the range of Category 4 when classifying according to the gas classification, and classification is not possible because it cannot be judged if LD50 is Category 5 or "Not classified". EU-Annex I: R20 is equivalent to the GHS Category 3-4.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data
3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Classification not possible - - - - Since the gene mutation test or UDS test employing the CHO cell in vitro do not show toxicity but toxicity is shown in SCE test employing a CHO cell, there is a possibility of chromosomal aberration in the test employing mammalian cultured cells (PATTY (5th, 2005)). However, since there was no data of in vivo examination, it was considered that classification is not possible.
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since deformation in fetuses' fingers were observed in the developmental toxicity study via oral administration using mice at the dose level where general toxicity was not found in parent animals using mice and increase in fetal death was observed (PATTY(5th,2005)) at the dose level where general toxicity was not found in parent animals in the developmental study via forced oral administration using rats, it was classified in Category 1B. EU-Annex I is Cat. 2; R60/R61, corresponding to GHS Category 1B.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since there is a description that inhalation exposure causes conditions, such as giddiness and breathing difficulty, and oral exposure causes nausea and atypical absence in humans (HSDB (2002)), it was classified into Category 3 (Narcotic effects)
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although it has been described that the impact on avoidance reaction and the growth reduction are seen in 10 days inhalation administration test employing rats (1,000 ppm, 4hr/day) (PATTY (5th, 2005)), since the exposure periods are shorter than 14 days which are provided in the technical indicator , it was determined that classification is not possible due to insufficient information.
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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