GHS Classification Result （Revision of the past classification result）

Chemical Name：2-Aminoethanol
CAS：141-43-5

Result：
ID: 8
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） - - - - - -
1 Acute toxicity （Dermal） - - - - - -
1 Acute toxicity （Inhalation: Gases） - - - - - -
1 Acute toxicity （Inhalation: Vapours） - - - - - -
1 Acute toxicity （Inhalation: Dusts and mists） - - - - - -
2 Skin corrosion/irritation - - - - - -
3 Serious eye damage/eye irritation - - - - - -
4 Respiratory sensitization Classification not possible - - - - A human data as a basis for classification in the three-ministry GHS classification is a case exposed to the mixture with unknown composition containing 2-aminoethanol. Moreover, in BUA Report 202 in which this data is quoted, it is concluded that symptoms such as asthma and rhinitis in occupational exposure have been clarified to be derived from monoethanolamine alone. Therefore, classification is not possible as "Category 1" based on the above-mentioned human data since the data have insufficient conditions and results for determining the relationship between exposure and generating condition of this substance alone. Since there is no other data on respiratory-organs sensitization, it may be reasonable to correct the GHS classification from "Category 1" to "Classification not possible", even with the lack of data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There is a human case of occupational exposure on some 100 people, showing positive results in the study employing the non-diluted substance. "A possibility that this case has detected cross-reactivity" mentioned in the public comments is considered to be low. Therefore, "Category 1" of three-ministry GHS classification is considered proper.
5 Germ cell mutagenicity - - - - - -
6 Carcinogenicity - - - - - -
7 Reproductive toxicity Classification not possible - - - - Whether it is correct judgemnt or not is doubtful to adopt newborns' hydronephrosis (pyelectasia) shown in Mankes report as evidence to consider that "Category 2" is appropriate. Since the group administered with 2-aminoethanol shows apparently greater values than the control group with regard to the ratio of the newborns with whom cetain effects were observed and the ratio of newborns with whom significant effects (malform) were observed, it is considered that administration gave effects on them. Since these effects decrease, however, at a high dose level, it may be too soon to judge based on nothing but these results. .Therefore, it is considered appropriate to think that GHS Classification is "Classification not possible."
8 Specific target organ toxicity - Single exposure - - - - - -
9 Specific target organ toxicity - Repeated exposure - - - - - -
10 Aspiration hazard - - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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