GHS Classification Result （Revision of the past classification result）

Chemical Name：Diantimony trioxide
CAS：1309-64-4

Result：
ID: 250
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） - - - - - -
1 Acute toxicity （Dermal） - - - - - -
1 Acute toxicity （Inhalation: Gases） - - - - - -
1 Acute toxicity （Inhalation: Vapours） - - - - - -
1 Acute toxicity （Inhalation: Dusts and mists） - - - - - -
2 Skin corrosion/irritation - - - - - -
3 Serious eye damage/eye irritation Not classified - - - - In the three-ministry GHS classification, it is classified as "Category 2B " based on the test result of "Mild irritation to eyes of rabbits at 100mg dose" indicated in RTECS. On the other hand, in the public comment literature (LPT (2005)), it is clearly specified as "non-irritating" from the test result employing a rabbit of the GLP test organization according to the OECD test guidelines. That is, there exists each one case of positive and negative in the test employing a rabbit. According to the public comments, the literature of LPT (2005) is not open to the public. But it was available through common routes and was used for our reference. The former study with the positive result was performed in 1972, and the details in description of the substance used and the symptoms are unknown. On the other hand, the latter study with the negative result was performed in conformity with the the OECD Test Guideline, 2002, and the details in the origin and description of the substance and symptoms generated are described. Therefore, it may be considered that the latter study with the negative result is more reliable than the former one. Therefore, it is considered proper that classification of the substance should be corrected from "Category 2B" to "Not classified".
4 Respiratory sensitization - - - - - -
4 Skin sensitization - - - - - -
5 Germ cell mutagenicity - - - - - -
6 Carcinogenicity - - - - - -
7 Reproductive toxicity Not classified - - - - When the in vivo developmental study of rats provided in the public comment in the fiscal year of Heisei 19 was thoroughly reviewed, it was confirmed that no case example of animal death was caused during the study period and that there was no effect related with the administration, based on the clinical test of mothers' body, body weight, food consumptions, visual test, implantation data in uterus on the 20th day of pregnancy, gender ratios among fetuses, body weight, data for the distance from head to bottom and other tests. Therefore, the result that was changed to "Classification not possible" in the report of the fiscal year of Heisei 18 shall be further changed to "Not classified."
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system) Warning H371: May cause damage to organs (respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		For the heart, since such description is not found in the original literature which is considered as the judgment basis of three-ministry GHS classification result, it is appropriate to delete the "Category 1 (heart)" of GHS classification. For respiratory system, it is "Category 2" when the original literature of the collection of CERI hazard data used on the judgment basis of the three-ministry GHS classification result is scrutinized in succession for determination. On the other hand, it is "Not classified", judging from the literature shown in the public comment. Since all of them differ in the classification by a useful data, it is appropriate to consider it as "Category 2" from a perspective of making risk well-known. From the above, "Category 1 (heart) and Category 2 (respiratory organs)" are corrected to "Category 2 (respiratory organs)." In addition, although the literature (LPT, 2005) offered by the public comments in 2007 fiscal year was said to be not opened to the public by the public comments, it was available through common routes and was used for our reference.
9 Specific target organ toxicity - Repeated exposure - - - - - -
10 Aspiration hazard - - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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