GHS Classification Result （Revision of the past classification result）

Chemical Name：2-(Dimethylamino)ethyl methacrylate
CAS：2867-47-2

Result：
ID: 501
Classifier: Ministry of Economy, Trade and Industry （METI）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives - - - - - -
2 Flammable gases （including chemically unstable gases） - - - - - -
3 Aerosols - - - - - -
4 Oxidizing gases - - - - - -
5 Gases under pressure - - - - - -
6 Flammable liquids - - - - - -
7 Flammable solids - - - - - -
8 Self-reactive substances and mixtures - - - - - -
9 Pyrophoric liquids - - - - - -
10 Pyrophoric solids - - - - - -
11 Self-heating substances and mixtures - - - - - -
12 Substances and mixtures which, in contact with water, emit flammable gases - - - - - -
13 Oxidizing liquids - - - - - -
14 Oxidizing solids - - - - - -
15 Organic peroxides - - - - - -
16 Corrosive to metals - - - - - -

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. As pointed out in public comment, it is modified to "Category 5" based on two data of (LD50>2000 mg/kg, LD50=2,659 mg/kg) which is considered to have reliability in SIDS (SIAR) adopting LD50 value being larger than 2000 mg/kg.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. According to notes (f) (ii) of table 3.1.1 in the U.N. documents 3.1, it is modified to "Category 5."
1 Acute toxicity （Inhalation: Gases） - - - - - -
1 Acute toxicity （Inhalation: Vapours） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		2.28 mg/L
1 Acute toxicity （Inhalation: Dusts and mists） - - - - - -
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is classified as "Category 1A-1C"in the three-ministry GHS division. Since UN GHS Document 3.2.2.4.2 says, "For those authorities wanting more than one designation for corrosion, up to three sub-categories are provided within the corrosive category." subdividing is not essential. It is therefore preferable to modify "Category 1A-1C" to "Category 1" from the view point of text representation as well.
3 Serious eye damage/eye irritation - - - - - -
4 Respiratory sensitization - - - - - -
4 Skin sensitization - - - - - -
5 Germ cell mutagenicity - - - - - -
6 Carcinogenicity - - - - - -
7 Reproductive toxicity Classification not possible - - - - Since the base for 3-Ministry GHS Classification is based on the changes observed from the death of mother animals (3 out of 12 animals) and the dose level (1,000mg/kg/day) where significant effects were identified, it is not appropriate to make it the base for GHS Classification. Moreover, although no effects on reproduction are observed at this dose level (200mg/kg/day), it cannot be judged whether there may be effects on reproduction or not at the dose level of 200 - 1,000mg/kg/day. Therefore, it is classified into "Classification not possible."
8 Specific target organ toxicity - Single exposure - - - - - -
9 Specific target organ toxicity - Repeated exposure - - - - - -
10 Aspiration hazard - - - - - -

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） - - - - - -
11 Hazardous to the aquatic environment （Long-term） - - - - - -


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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