GHS Classification Result

Chemical Name:Pentaerythrite tetranitrate
CAS:78-11-5

Result:
ID: 07-D13
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2007
Reference Manual: GHS Classification Manual (10 Feb, 2006)
Technical Guidance Document on the GHS Classification (6 Dec, 2005)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Unstable Explosive Danger H200: Unstable Explosive P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P372: Explosion risk in case of fire.
P374: Fight fire with normal precautions from a reasonable distance.
P380: Evacuate area.
P401: Store ...
P501: Dispose of contents/container to ...
Since the substance, which is wetted with less than 25% water by mass and containing less than 15% stabilizer by mass, is prohibited from being transported (Ship Safety Act / Article 5-1(t) of Public Notice of the Ministry of Transport, No.549 of 1979), we determined that it is an unstable explosive. (If the substance is wetted with not less than 25% water by mass or containing not less than 15% stabilizer by mass, it is defined as UN0150 and Division 1.1. The substance containing >= 7% wax is defined as UN0411 and Division 1.1.)
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - Since the substance is classified as an explosive, classification as a self-reactive substance is not applicable.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb,Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on its rat LD50 of 1660 mg/kg (RTECS, accessed in August 2007), the substance was classified into Category 4.
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible - - - - Regarding in vitro tests conducted on this substance, both an Ames test and a chromosomal aberration test using cultured cells gave negative results (NTP TR 365, 1989). Due to lack of in vivo test results, classification is not possible due to insufficient data available.
6 Carcinogenicity Not classified - - - - A 2-year mixed diet administration test using rats resulted in a slight increase in incidences of neoplasms of the Zymbal gland in rat groups of both sexes treated with PETN and NF (a mixture of this substance and D-lactose in a 1:4 ratio) (NTP TR 365 (1989)). However, according to NTP TR 365 (1989), this study does not provided sufficient evidence that this substance is carcinogenic. Similarly, in another 2-year mixed diet administration test using mice (maximum dose: 50000 ppm), the substance was evaluated to be not carcinogenic. While no classification of the substance has been carried out by authorized agencies, no clear carcinogenic effects were detected in carcinogenicity studies using two species of rodents. Thus, the substance has been classified into the "Not classified" category by specialists.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Not classified - - - - In mixed diet administration tests using rats (14-week test) or mice (13-week test), no clear toxic effects were observed at doses above the upper limit of the range of Category 2 guidance values (NTP TR 365 (1989)). Thus, the substance was classified into the "Not classified" category.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Its 48-hour LC50 is reported to be 292 mg/L for crustaceans (Daphnia magna) (AQUIRE, 2007; Bentley et al., 1975). However, this value is higher than its water solubility of 43 mg/L (HSDB, 2007). Since no reliable test results are available, classification is not possible. As additional background information, another toxicity test on fish, which is reported together with the above crustacean test, was an inadequate test (considered as a preliminary test with a limited sample size). In addition, since exposure concentrations reported are higher than the water solubility of this substance, this test is also not very reliable.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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