GHS Classification Result

Chemical Name：Cyclotetramethylenetetranitramine
CAS：2691-41-0

Result：
ID: 07-D19
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Unstable Explosive Danger H200: Unstable Explosive P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P372: Explosion risk in case of fire.
P374: Fight fire with normal precautions from a reasonable distance.
P380: Evacuate area.
P401: Store ...
P501: Dispose of contents/container to ... 		Since the substance, which is wetted with less than 15% water by mass, is prohibited from being transported (Ship Safety Act / Article 5-1(v) of Public Notice of the Ministry of Transport, No.549 of 1979), we determined that it is an unstable explosive. (If the substance is wetted with not less than 15% water by mass, it is defined as UN0226 and Division 1.1. In addition, the desensitized substance is identified as UN0484 and Division 1.1.)
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - Since the substance is classified as an explosive, classification as a self-reactive substance is not applicable.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Given that its autoignition point is 234degC (ICSC (J) 2005), we determined that the substance does not ignite spontaneously in contact with air at room temperature and classified it into the "Not classified" category.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb,Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - No data available.
15 Organic peroxides Not applicable - - - - Containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. The rat LD50 values reported are 5500 mg/kg (males), 6400 mg/kg (females) (IRIS (accessed in August 2007), ATSDR (1997)), and 2300 mg/kg (PATTY (5th, 2005)). Based on the lowest LD50 value, the substance was classified into Category 5.
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		No rat LD50 has been acquired, but a rat LD0 of 4239 mg/kg is reported (ATSDR (1997)) and so is a rabbit LD50 of 634 mg/kg (ARSDR 1997). Comparing these two values, the rabbit LD50, which is lower value of two, was selected as the basis for the classification of the substance into Category 3.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Mild irritation of the skin was noted in rabbits after a dermal exposure to 109 mg/kg of the substance (ATSDR (1997)). Similarly, mild irritation of the skin was seen in rabbits after a dermal application of 500 mg of this substance (RTECS (accessed in August 2007)). Based on these reports, the substance was classified into Category 3.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - After three of 558 munitions workers developed lupus erythematosus, a study was conducted to investigate the relationship between the incidences and immunocompetence (ATSDR (1997)). Compared to an unexposed control group, the prevalence of antinuclear antibodies, which is a biological indicator of lupus erythematosus, was not significantly different in exposed workers (ATSDR (1997)). However, since munitions workers were also exposed to other substances including TNT and RDX in addition to this substance, no clear conclusion was drawn (ATSDR (1997)). In another study, a guinea pig skin sensitization test gave negative results, but no details such as test methods are provided. Thus, due to insufficient information available, the substance was classified into the "Classification not possible" category.
5 Germ cell mutagenicity Classification not possible - - - - While an Ames test gave negative results (IRIS (2007)), no in vivo test results are available. Thus, classification is not possible.
6 Carcinogenicity Not classified - - - - Based on the EPA's evaluation of the substance into Category D (IRIS (2007)), the substance was classified into the "Not classified" category.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, kidney) Danger H370: Causes damage to organs (central nervous system, kidney) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In dermal administration of the substance to rabbits, the following were noted at the dose of 168 mg/kg: effects on the central nervous system including convulsions, hyperkinesias, hypokinesia, changes in aggressive behavior; histological damage to the kidney including tubular dilation, fibrosis, atrophy, and atrophy of the glomerulus (ATSDR (1997)). Since we think that damage to the central nervous system and kidney occurs at doses that fall under Category 1 guidance values, the substance was classified into Category 1 (central nervous system and kidney).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In a 13-week mixed diet administration test using rats, liver damage was seen in males treated with 150 mg/kg/day or higher doses, and kidney damage was noted in females treated with 270 mg/kg/day or higher doses. NOAEL were 50 mg/kg/day for males and 115 mg/kg/day for females (IRIS (1988)). The LOAEL for liver damage in males is slightly above the upper limit of Category 2 guidance values and NOAEL is within the range of Category 2 guidance values, indicating that liver damage may occur at doses that fall under Category 2. Thus, the substance was classified into Category 2 for its toxicity to the liver. Regarding female rats, the LOAEL and NOAEL for kidney damage are reported to be 270 mg/kg/day and 115 mg/kg/day, respectively. Since the NOAEL is above the upper limit of Category 2 guidance values, we determined that the substance falls under the "Not classified" category for its toxicity to the kidney.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - Regarding this substance, its 96-hour EC50 for algae (Selenastrum) is > 32 mg/L, 48-hour LC50 for crustaceans (Daphnia magna) is > 32 mg/L, and 96-hour LC50 for fish (flathead minnow, rainbow trout, and bluegills) is > 32 mg/L (AQUIRE, 2007; Bentley et al., 1975). Given that its water solubility is 5mg/L (PHYSPROP Database, 2007), the substance is presumably not toxic and was classified into the "Not classified" category.
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Any acute toxic effects are not reported for this substance up to its water solubility concentration of 5 mg/L (PHYSPROP Database, 2007), it is estimated not to be rapidly degradable (BIOWIN), and its potential for bioaccumulation is likely low (log Kow = 0.16 (PHYSPROP Database, 2007). Based on this information, the substance was classified into the "Not classified" category.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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