GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：N-Nitrosodiethylamine
CAS：55-18-5
Result：
| ID: | 3 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2007 |
| Reference Manual: |
GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | It contains chemical groups (N-nitroso group) associated with explosive properties. Since no test results are available, classification is not possible. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Classification not possible | - | - | - | - | Classification not possible due to lack of data. (According to New Jersey Department of Health and Senior Services, Hazardous Substance Fact Sheet, it is combustible. Industrial Safety and Health Act designated the substance as an inflammable dangerous good.) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | It contains chemical groups (N-nitroso group) associated with explosive properties. Since no test results are available, classification is not possible. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | It is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to nitrogen. Since no test results based on standardized testing methods are available, classification is not possible. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Since its LD50 was found to be 280 mg/kg for rats that were orally administered (Patty 5th, 2001), we determined the substance is in Category 3. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | It is reported to be a skin irritant (HSFS, 1999); however, details of the study including evidence for the conclusion are not provided. Thus, classification is not possible due to insufficient data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | It is reported to be an eye irritant (HSFS, 1999), but details of the study including evidence for the conclusion were not provided. Thus, classification is not possible due to insufficient test results available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although dominant lethal tests on mice gave negative results (IARC 17, 1978), both micronucleus tests using rats that underwent intraperitoneal administration, and DNA damage tests using rats that underwent oral administration gave positive results (RTECS (accessed in August 2007)). Thus, the substance was classified into Category 2. According to RTECS, specific locus tests using mice gave positive results, but details of the study cannot be verified; so this study cannot be evaluated for classification. |
| 6 | Carcinogenicity | Category 1B |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Because the substance is rated as Group 2A in IARC S7 (1987) and R according to the U.S. NTP (2005), it was classified into Category 1B. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data. There is a description that fetal mortality increased in pregnant animals in the test in which 0.1-0.3 mg of this substance was administered into the placenta on day 13 of pregnancy (IARC 17, 1978). However, as the test was conducted using unconventional methods, these results were not evaluated for classification. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | IARC 17 (1978) reported that effects of the substance on the liver were detected in an animal study. However, since details of the study such as administration doses are not provided, classification is not possible. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Since its 96-hour EC50 is 10.2 mg/L for algae (Selenastrum) (Aquire, 2007), the substance was classified into Category 3 for acute toxicity. |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Its acute toxicity is Category 3, and its potential for bioaccumulation is expected to be low (logPow = 0.48, Physprop). However, because it is not rapidly degradable (BIOWIN 2007), the substance was classified into Category 3 for chronic toxicity. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |