GHS Classification Result

Chemical Name：1,2-Diphenylhydrazine
CAS：122-66-7

Result：
ID: 16
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - It contains chemical groups (hydrazine group) associated with explosive properties. Since no further information is available, classification is not possible.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data. (it is reported to be combustible (ICSC))
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (hydrazine group) associated with explosive properties. Since no further information is available, classification is not possible. (It belongs to Category V of hazardous materials: self-reactive substances, by the Fire Service Act.)
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since its rat LD50 = approx. 300 mg/kg according to the DFG (1998), the substance was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - According to HSFS (1999), it can irritate the skin and eyes. However, since there is no clear evidence that supports this conclusion, the substance was classified into the "Classification not possible" category.
3 Serious eye damage/eye irritation Classification not possible - - - - According to HSFS (1999), it can irritate the skin and eyes. However, since there is no clear evidence that supports this conclusion, the substance was classified into the "Classification not possible" category.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - According to HSFS (1999), this substance may cause skin allergies, and if they progress, future re-exposure to even very low concentrations of this substance may cause itchiness and rash on the skin. However, since there is no clear evidence that supports this conclusion, the substance was classified into the "Classification not possible" category.
5 Germ cell mutagenicity Classification not possible - - - - Both Ames test and in vitro chromosomal aberration test produced positive results (DFG (1998)). In addition, comet assay with mouse somatic cells gave positive results (RTECS (accessed in September 2007)). However, no test results in in-vivo mutagenicity studies are available, and the evaluation of the comet assay has not been finalized. As such, the substance was classified into the "Classification not possible" category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is rated as "B2" by the EPA (U.S. EPA, 1991) and "R" by the NTP (U.S. NTP, 2005). Based on these ratings, the substance was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - According to HSFS (1999), swallowing this substance can irritate the nose and throat in humans. However, since there is no clear evidence that supports this conclusion, the substance was classified into the "Classification not possible" category.
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In an oral administration test using mice, necrosis of the liver was noted at doses that fall under the range of Category 2 guidance values (ATSDR (1990)). Thus, the substance was classified into Category 2 for the liver.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 96-hour LC50 for medaka is 0.043 mg/L (Ministry of the Environment, 2002), the substance was classified into Category 1 for its acute toxicity.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Its classification for acute toxicity is Category 1, it is not rapidly degradable (BIOWIN 2007), its potential for bioaccumulation is low (logPow = 2.94, SRC 2005), and NOEC is < 1 mg/L. Based on this information, the substance was classified into Category 1 for its chronic toxicity.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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