GHS Classification Result

Chemical Name：1-Chloro-2-methylpropene
CAS：513-37-1

Result：
ID: 36
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid (liquid (Merck, 14th))
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Liquid (liquid (Merck, 14th))
5 Gases under pressure Not applicable - - - - Liquid (liquid (Merck, 14th))
6 Flammable liquids Classification not possible - - - - No data available.
7 Flammable solids Not applicable - - - - Liquid (liquid (Merck, 14th))
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups associated with self-reactive properties (C=C) and does not contain chemical groups associated with explosive properties. Since no further information is available, classification is not possible.
9 Pyrophoric liquids Classification not possible - - - - No data available.
10 Pyrophoric solids Not applicable - - - - Liquid (liquid (Merck, 14th))
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - The substance contains chlorine (but not fluorine or oxygen), which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid (liquid (Merck, 14th))
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since its rat LD50 is 150 mg/kg (RTECS, accessed in September 2007), the substance was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Liquid
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Given that its rat LC50 (4 hours) = 0.4 mg/L (= 108 ppm) (RTECS, accessed in September 2007) and its saturated vapour pressure concentration (1000000*212 mmHg*0.1333/101) = 279798 ppm, we determined that the experiment was conducted in a vaporous state. Under this condition, the substance was classified into Category 1.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		With regard to in vivo mutagenicity tests using somatic cells, intraperitoneal administration tests were conducted using mice or rats in which micronuclei were induced in bone marrow cells (NTP DB (accessed in September 2007)). Since test results in in-vivo genotoxicity tests using germ cells have not been acquired, the substance was classified into Category 2.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is rated as "Group 2B" in IARC S7 (1987), "2B" in the Recommendations of Occupational Exposure Limits (2007), and "R" by the U.S. NTP (2005). Based on these ratings, the substance was classified into Category 2.
7 Reproductive toxicity Classification not possible - - - - No data available.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		According to HSDB (2003), the substance is irritating to respiratory tracts in humans. Thus, it was classified into Category 3 (respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 2 (lymphatic system) Warning H373: May cause damage to organs through prolonged or repeated exposure (lymphatic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In 13-week forced oral administration test using mice, necrosis of lymphopoietic cells, leading to atrophy of the thymus, lymph nodes and spleen, was observed (IARC 63, 1995). Based on this study, we concluded that the lymph system is the target organ of this substance. Regarding animal tests, effects of the substance were seen at doses that fall in the range of Category 2 guidance values. In conclusion, the substance was classified into Category 2 (lymph system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - No data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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