GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Isobutyl nitrite
CAS：542-56-3
Result：
| ID: | 38 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2007 |
| Reference Manual: |
GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | - | It contains chemical groups (nitrite ester) associated with explosive properties. Due to lack of test results, classification is not possible. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (colorless liq (Merck, 14th)) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (colorless liq (Merck, 14th)) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Its flash point reported by the ICSC is -21degC and its boiling point reported by the CRC is 67degC. Based on this information, the substance was classified into Category 2. (EU Risk Phrase for this substance is R11: highly flammable.) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (colorless liq (Merck, 14th)) |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | It contains chemical groups (nitrite ester) associated with explosive properties. Due to lack of test results, classification is not possible. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (colorless liq (Merck, 14th)) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | It is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to nitrogen. Since no test results based on standardized testing methods are available, classification is not possible. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Since its rat LD50 is 410 mg/kg (RTECS, accessed in September 2007), the substance was classified into Category 4 |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since the substance is a liquid, it was classified into the "Not applicable" category. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 3 |
|
Danger | H331: Toxic if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P311: Call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Its rat LC50 (4 hour) = 777 ppm (=3.28 mg/L) (RTECS, accessed in September 2007), and its saturated vapour pressure concentration (1000000*1.3kPa/101) is 12871 ppm. Given this information, we determined that the experiment was conducted in a vaporous state, and classified the substance into Category 3. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Since no appropriate in vivo test results have been acquired, classification is not possible. As background notes, mice exposed to this substance by inhalation showed induction of micronuclei in the peripheral blood erythrocytes (ACGIH, 2003; NTP DB, accessed in September 2007). However, since the test was conducted using non-standardized methods, this test was excluded for classification purposes. |
| 6 | Carcinogenicity | Category 2 |
|
Warning | H351: Suspected of causing cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since ACGIH (2007) rated the substance as A3, it was classified into Category 2. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood system), Category 2 (respiratory system) |
|
Danger Warning |
H370: Causes damage to organs (blood system) H371: May cause damage to organs (respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. |
Symptoms seen in users of this substance who were transported to emergency rooms include arterial hypoxia, cyanosis, dyspnea, and lethargy. In some cases, nausea and nasal irritation were also noted (ACGIH, 2003). This substance may cause fatal toxic methemoglobinemia if ingested; in fact, a case with a fatal outcome has been presented (HSDB, 2003). In addition, a case report of severe and prolonged tracheobronchitis in a 23-year-old male, following the inhalation of this substance has been presented (HSDB, 2003). Based on these reports, we noted the effects on the blood system and respiratory system, and classified the substance into Category 1 for the blood system and Category 2 for the respiratory system. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood system, respiratory system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (blood system, respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In inhalation exposure tests using mice or rats that received this substance for 13 weeks (6 hours/day and 5 days/week), a very mild anemia and methemoglobinemia, epithelial cell hyperplasia of the nasal mucosa, and hyperplasia of the bronchial epithelium were observed (U.S. NTP TR 448, 1996). Based on these reports, we considered the blood system and respiratory system to be target organs. Since these symptoms were seen at doses that fall under Category 2 guidance values, the substance was classified into Category 2 for the blood system and respiratory system. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
|
Reference Manual |
|
|
Definitions / Abbreviations |
|
|
Model Label by MHLW |
MHLW Website （in Japanese Only） |
|
Model SDS by MHLW |
MHLW Website （in Japanese Only） |