GHS Classification Result

Chemical Name：N-Methyl-N-nitrosourea
CAS：684-93-5

Result：
ID: 46
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - It contains chemical groups (N-nitroso group) associated with explosive properties. Since no test results are available, classification is not possible.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (N-nitroso group) associated with explosive properties. Since no test results are available, classification is not possible.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - It is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to nitrogen. Since no test results based on standardized testing methods are available, classification is not possible.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since its rat LD50 = 110 mg/kg (IARC 17, 1978), the substance was classified into Category 3.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - Nitrosamide compounds are generally skin irritants, vesicants, or skin sensitizers (Patty, 5th, 2001). Although this report indicates that the substance is irritating, classification of the substance is not possible based only on this report.
3 Serious eye damage/eye irritation Classification not possible - - - - Nitrosamide compounds are generally skin irritants, vesicants, or skin sensitizers (Patty, 5th, 2001). Although this report indicates that the substance is irritating, classification of the substance is not possible based only on this report.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		This substance is known to cause skin dermatitis, which appears to be sensitization dermatitis rather than primary irritation (HSDB, 2003). In addition, nitrosamide compounds are generally skin irritants, vesicants, or skin sensitizers (Patty, 5th, 2001). Based on these descriptions, the substance was classified into Category 1.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive results obtained in mouse dominant lethal test and mouse bone marrow micronucleus test (IARC 17, 1978; Mutat Res, 352, 159-167, 1996), the substance was classified into Category 1B.
6 Carcinogenicity Category 1B Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is rated as "Group 2A" by IARC S7 (1987) and "R" by the U.S. NTP (2005). Based on these ratings, the substance was classified into Category 1B.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In rats that received single intraperitoneal administration of the substance on day 2 of gestation, abnormalities of the brain were noted in most surviving fetuses (IARC 17 (1978)). In rats administered the substance on day 11-13 of gestation, malformation of the limbs were seen in 100% of fetuses. In addition, increased incidences of micrognathia, hydrocephaly, and microcephaly were noted in rats administered on day 13-14, day 12, and day 12-16 of gestation, respectively. And retarded development was seen in progeny that was born from parental animals that were administered the substance during the organogenic period. According to Patty 5th (2001), non-oral administration of this substance at 20 mg/kg to rats was associated with clear cases of teratogenic effects. Furthermore, according to HSDB (2003), in a study in which mice received single intraperitoneal administration of this substance on day 2 of pregnancy, all fetuses died at doses that did not show toxic effects to parental animals?the toxic dose range for fetuses and their development was one order magnitude lower than the toxic dose range for adult animals. Based on these reports, the substance was classified into Category 1B as toxic effects on reproduction occur at doses that do not induce general toxic effects on parental animals.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In Chinese hamsters administered the substance, damage to the pancreas and diabetes were noted (IARC 17 (1978)). However, since details such as route of administration were not provided, classification is not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - No data available.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Classification not possible - - - - Insufficient data available.
11 Hazardous to the aquatic environment （Long-term） Classification not possible - - - - No data available.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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