GHS Classification Result

Chemical Name：2,4-Dichlorophenyl 4-nitrophenyl ether; Nitrofen
CAS：1836-75-5

Result：
ID: 53
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - It contains chemical groups (nitro group) associated with explosive properties. Since no test results are available, classification is not possible.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data. (it is reported to be combustible (ICSC).)
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (nitro group) associated with explosive properties. Since no test results are available, classification is not possible.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Since its autoignition point is > 400degC (IUCLID, 2007), it does not ignite at room temperature.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Classification not possible - - - - It is an organic compound containing chlorine and oxygen (but not fluorine), with the chlorine chemically bonded only to carbon or hydrogen, and the oxygen chemically bonded to nitrogen. Since no test results based on standardized testing methods are available, classification is not possible.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the report that its rat LD50 = 740 mg/kg (IARC, 1983), the substance was classified into Category 4.
1 Acute toxicity （Dermal） Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the report that its rat LD50 = 5000 mg/kg (IARC, 1983), the substance was classified into Category 5.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - WHO/Pesticide residues in food (1983) reported that the LD50 = 205 mg/L for both female and male rats (the substance was given as 25% emulsion for 1 hour). Since the test was not of a technical product, it was excluded as a reference for classification.
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		This substance has been reported to have irritating effects on the skin and eyes of people with occupational exposure (PDS (1996)). Thus, it was classified into Category 2.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		This substance has been reported to have irritating effects on the skin and eyes of people with occupational -exposure (PDS (1996)). Thus, it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		In human exposure studies, patch tests produced positive results (HSDB, 2003). Thus, the substance was classified into Category 1.
5 Germ cell mutagenicity Not classified - - - - Mouse spot tests, a kind of in vivo mutagenicity test using somatic cell, gave negative results (IUCLID, 2000). In addition, rats that received oral administration of the substance did not show chromosomal aberrations in bone marrow cells (IARC 30, 1983). Based on these results, the substance was classified into the "Not classified" category.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It is rated as "Group 2B" by IARC S7 (1987) and "R" by the U.S. NTP (2005). Based on these ratings, the substance was classified into Category 2.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In oral and dermal applications of this substance to pregnant rats, malformations such as cardiac malformations, diaphragmatic hernias, and hydronephrosis were noted in pups that were born from exposed mothers at doses that did not show toxic effects in maternal animals (PDS 84 (1996)). In addition, hydrocephalus and microphthalmia were seen in progeny of mice that received oral administration of the substance during gestation (IARC 30 (1983)). Also, oral administration of the substance to pregnant rats was associated with increased fetal deaths and lowered postnatal survival rates. These reports demonstrated that clear cases of reproductive toxicity become apparent at doses that do not show maternal toxicity. Thus, the substance was classified into Category 1B.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		A man exposed to commercial formulation of nitrofen complained of upper respiratory tract irritation (PDS 84, 1996), and acute toxic effects of this substance are mostly on respiratory tracts and the nervous system (IARC 30, 1983). Based on these reports, the substance was classified into Category 3 (respiratory tract irritation). Regarding its effect on the nervous system, details such as the relationship between the effects and doses were not found. Thus, classification was not carried out for the nervous system.
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system), Category 2 (nervous system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (blood system)
H373: May cause damage to organs through prolonged or repeated exposure (nervous system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In agricultural workers who experienced excessive exposure to nitrofen, reduction in hemoglobin and leukocyte counts was noted (NTP TR 184, 1979), and chronic occupational exposure without protection resulted in central nervous system disturbances and anemia (HSDB, 2003). Based on these reports, the substance was classified into Category 1 (blood system) and Category 2 (nervous system).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since its 48-hour LC50 for crustaceans (a species of the Ceriodaphnia) is 0.216 mg/L (ECOTOX, 2007), the substance was classified into Category 1 for acute toxicity.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Its classification for acute toxicity is Category 1, it is not rapidly degradable (BIOWIN 2007), and logPow = 4.64 (SRC 2005). Based on this information, the substance was classified into Category 1 for chronic toxicity.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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