Chemical Name：2,2-Bis(bromomethyl)propane-1,3-diol; Dibromoneopentylglycol
CAS：3296-90-0

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Since its rat LD50 is 3458 mg/kg in an oral administration test (IARC vol. 77 (2000)), the substance was classified into Category 5.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since the substance is a solid (GHS definition), it was classified into the "Not applicable" category.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available.
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In vivo micronucleus test using mouse bone marrow cells and that using peripheral blood both gave positive results (IARC vol. 77 (2000)), and no test results in in-vivo mutagenicity tests using germ cells have been conducted. Based on this information, the substance was classified into Category 2.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It is rated as "Group 2B" by the IARC (IARC vol. 77 2000), "R" by the NTP (NTP 2005), and "Group 2B" by Japan Society for Occupational Health (Recommendations of Occupational Exposure limits 2007). Based on these ratings, the substance was classified into Category 2.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	In a two-generation reproduction test using mice, decreased body weight in pups, decreased number of live pups born per litter, increased number of fetal deaths, and lowered fertility rates were noted (IARC vol. 77 (2000)). Based on this report, the substance was classified into Category 2.
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	In a 90-day repeated oral administration test using rats or mice, papillary degeneration and necrosis of the renal papilla, and hyperplasia of the urinary bladder were noted (NTP TR 452 (1996)). Since these symptoms occurred at doses above Category 2 guidance values, and no other test results are available, classification is not possible due to insufficient test results available.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available.