Chemical Name:Sodium chromate
CAS:7775-11-3
ID: | 65 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2007 |
Reference Manual: |
GHS Classification Manual (10 Feb, 2006) Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid (GHS definition) |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
7 | Flammable solids | Not classified | - | - | - | - | Non-combustible inorganic compound (it is reported to be not combustible (ICSC)). |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible inorganic compound. |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-combustible inorganic compound. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | There is a product made of this substance dissolved in water. |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data. |
15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 2 | Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Since its rat LD50 = 40 mg/kg by oral administration (EU-RAR (2005)), the substance was classified into Category 2. | |
1 | Acute toxicity (Dermal) | Category 4 | Warning | H312: Harmful in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Since its rabbit LD50 = 1330 mg/kg (EU-RAR (2002)), the substance was classified into Category 4. | |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Since the substance is a solid (GHS definition), it was classified into the "Not applicable" category. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 | Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Since its rat LC50 = 0.104 mg/L (4 hours) (EU-RAR (2005)), the substance was classified into Category 2. | |
2 | Skin corrosion/irritation | Category 1 | Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the description that water-soluble Cr (VI) compounds are corrosive (EU-RAR (2005)), the substance was classified into Category 1. | |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Based on the description that water-soluble Cr (VI) compounds cause irreversible and severe damage to the eyes (EU-RAR (2005)), the substance was classified into Category 1. It has been classified into Category 1 for skin corrosion as well. | |
4 | Respiratory sensitization | Category 1 | Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Cr (VI) compounds containing sodium salts are reported to cause respiratory tract sensitization in humans (EU-RAR (2005)). Thus, the substance was classified into Category 1. | |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Cr (VI) compounds containing sodium salts are reported to cause skin sensitization in guinea pigs (EU-RAR (2005)). Thus, the substance was classified into Category 1. | |
5 | Germ cell mutagenicity | Category 2 | Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
In vivo alkaline elution assay gave positive results (IUCLID (2000)) and in inhalation exposure test using rats, DNA damage was found in the lung (RTECS accessed in October 2007). Since various in vitro tests gave positive results (IARC 49 (1990)) and water-soluble Cr (VI) compounds were suggested to be mutagenic in in-vivo system (EU-RAR (2005), IARC 49 (1990)), we classified the substance into Category 2. | |
6 | Carcinogenicity | Category 1A | Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Cr (VI) compounds are rated as "Group 1" by the IARC (IARC vol. 49 (1996)), "Group 2" by the EU (EU 2007), and "Group 1" by Japan Society for Occupational Health (Recommendations of Occupational Exposure Limits 2007). Based on these ratings, the substance was classified into Category 1A. | |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Since there are no test results available on this substance, classification is not possible. As related information, in developmental toxicity test in which potassium dichromate, a kind of Cr (VI) compounds, was applied to mice, increased premature births and dead fetuses and decreased number of fetuses per litter were noted (EU-RAR (2005)). |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system, kidney, liver) | Danger | H370: Causes damage to organs (respiratory system, kidney, liver) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
There is a report that inhalation by humans of aqueous solutions of Cr (VI) mists have resulted in necrosis of the bronchi and edemas of the lungs. In addition, swallowing of the substance by humans resulted in liver and kidney damage (EU-RAR (2005)). Based on these results, the substance was classified into Category 1 (respiratory system, kidney, and liver). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, kidney) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Repeated exposure to Cr (VI) including sodium chromate in humans resulted in respiratory system and kidney damage (EU-RAR (2005)). Based on this report, the substance was classified into Category 1 (respiratory system and kidney). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since 48-hour EC50 = 0.05 mg/L for crustaceans (Daphnia magna) (EU, 2005), the substance was classified into Category 1. | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Its classification for acute toxicity is Category 1; it is a metal compound and its movement in the water and its potential for bioaccumulation is unclear. Based on this information, the substance was classified into Category 1. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |