GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：(R)-1-Chloro-2,3-epoxypropane
CAS：51594-55-9
Result：
| ID: | 77 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2007 |
| Reference Manual: |
GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 3 |
|
Warning | H226: Flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
1) Since its flash point reported by ICSC is 33degC (closed cup), the substance was classified into Category 3 (RS isomers). 2) UN 2023, Class 3 (Subsidiary Risk) (RS isomers). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | UN 2023, Division 6.1, packing group II (RS isomers) |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Since its autoignition point is reported to be 385degC (Chemical Risk Information Platform (CHRIP)), it does not ignite at room temperature (RS isomers). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | The substance contains chlorine and oxygen (but not fluorine), which are chemically bonded only to carbon or hydrogen. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Classification not possible due to lack of data. (The EU's Risk Phrase for this substance is R34: causes burns.) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, rat oral LD50 for epichlorohydrin (CAS No. 106-89-8) is 90 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 1, 2002). Therefore, the substance was classified into Category 3. |
| 1 | Acute toxicity （Dermal） | Category 3 |
|
Danger | H311: Toxic in contact with skin |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, rat dermal LD50 for epichlorohydrin (CAS No. 106-89-8) is 754 mg/kg (EHC 33 (1984)). Therefore, the substance was classified into Category 3. |
| 1 | Acute toxicity （Inhalation: Gases） | Classification not possible | - | - | - | - | No data available. As relevant notes, epichlorohydrin (CAS No. 106-89-8) is a liquid by GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 2 |
|
Danger | H330: Fatal if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, rat LC50 for epichlorohydrin (CAS No. 106-89-8) by inhalation is 0.95 mg/L (4-hour exposure) or 250 ppm (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 1, 2002). Therefore, the substance was classified into Category 2. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Category 1 |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, epichlorohydrin (CAS No. 106-89-8) was found to be corrosive in skin irritation test using rabbits (Hazard Assessment Report (CERI, NITE) 2004). Therefore, the substance was classified into Category 1. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Although there are no test results available for its R isomers, epichlorohydrin (CAS No. 106-89-8) was found to be corrosive in eye irritation test using rabbits (Hazard Assessment Report (CERI, NITE) 2004). In addition, epichlorohydrin has been found to be skin corrosive. Therefore, the substance was classified into Category 1. |
| 4 | Respiratory sensitization | Category 1 |
|
Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, epichlorohydrin (CAS No. 106-89-8) is documented to cause chronic asthmatic bronchitis according to the human health effect data (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 1, 2002), and it is considered to be a respiratory sensitizer. Consequently, this substance was classified into Category 1. |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Although there are no test results available for its R isomers, epichlorohydrin (CAS No. 106-89-8) was found to be a skin sensitizer in guinea pigs (Hazard Assessment Report (CERI, NITE) 2004; ACGIH (2001); Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 1, 2002; EHC 33 (1984)). Consequently, this substance was classified into Category 1. |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since chromosomal aberrations and sister chromatid exchanges were observed in mouse bone marrow (RTECS accessed in November 2007), the substance was classified into Category 2. As additional background information, in vitro reverse mutation tests also gave positive results (RTECS accessed in November 2007). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | It is rated as "Carc. Cat. 2" by the EU; however, since we cannot verify the data that support the rating, we classified the substance into the "Classification not possible" category. As relevant notes, epichlorohydrin (CAS No. 106-89-8) is rated as "R" by the NTP and "Group 2A by the IARC (equivalent to GHS Category 1B) (US-NTP (2005), IARC 71 (1999)). |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Although there are no test results available for this substance, oral administration of epichlorohydrin (CAS No. 106-89-8) to rats showed effects on fertility of male rats such as sterility and decreased numbers of fertilized eggs and implantation (Hazard Assessment Report (CERI, NITE) 2004) while effects on parental animals were not clear. Based on this report, this substance was classified into Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (kidney), Category 2 (liver, digestive system), Category 3 (respiratory tract irritation) |
|
Danger Warning |
H370: Causes damage to organs (kidney) H371: May cause damage to organs (liver, digestive system) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Although there are no test results available for this substance, oral administration of epichlorohydrin (CAS No. 106-89-8) in animal tests resulted in kidney failure, fatty metamorphosis in the liver, necrosis of gastrointestinal tract, and respiratory tract irritation (Hazard Assessment Report (CERI, NITE) 2004). The effect of administration on the kidney was seen at doses that fall under Category 1 guidance values and that on the liver and gastrointestinal tract was noted at doses that fall under Category 2 guidance values. Based on the results above, the substance was classified into Category 1 for the kidney, Category 2 for the liver and digestive system, and Category 3 for respiratory tract irritation. |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (digestive system, respiratory system, kidney, liver) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (digestive system, respiratory system, kidney, liver) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Although there are no test results available for this substance, oral administration of epichlorohydrin (CAS No. 106-89-8) in animal tests resulted in inflammation and degeneration of the digestive system, hyperplasia of mucosa, and degeneration of renal tubules. In inhalation exposure tests, inflammation and degeneration of the respiratory system, pulmonary congestion and edema, hepatic congestion and necrosis, and atrophy of renal tubules were noted (Hazard Assessment Report (CERI, NITE) 2004). Since these effects were seen at doses that fall under Category 1 guidance values, the substance was classified into Category 1 for the digestive system, respiratory system, kidney, and liver. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |