GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Creosote oil
CAS：90640-84-9
Result：
| ID: | 88 |
| Classifier: | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| Year Classified: | FY2007 |
| Reference Manual: |
GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (IUCLID) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (IUCLID) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (IUCLID) |
| 6 | Flammable liquids | Classification not possible | - | - | - | - | Classification not possible due to lack of data. (Its flash point is reported to be > 90degC (IUCLID).) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (IUCLID) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Since its autoignition point is reported to be > 500degC (IUCLID), the substance does not ignite at room temperature. |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (IUCLID) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Classification not possible | - | - | - | - | Classification not possible due to lack of data. (The substance is not explosive, has no oxidizing properties, and is flammable according to IUCLID.) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (IUCLID) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available. As relevant background information, the average of five rat oral LD50 values reported for creosote oil (8001-58-9) (CICADS 62 (2004)) is 1523 mg/kg. Based on this value, creosote oil is classified into Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available. As relevant background information, because half of the rats treated with creosote oil (8001-58-9) at 15800 mg/kg died (ATSDR (2002)), creosote oil is classified into the "Not classified" category. |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available. |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. As relevant background information, while creosote oil (8001-58-9) differs in degrees of irritability depending on production locations of coal from which creosote is extracted, the U.S.-produced creosote oil is reported to be moderately irritating (ATSDR (2002)). Based on this information, creosote oil is classified into Category 2. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available. As relevant background information, there is one report that creosote oil (8001-68-9) is irritating to rabbit eyes and the irritating symptoms healed within 7 days (CICADS 62 (2004)). Based on this report, creosote oil is classified into Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. As relevant background information, creosote oil (8001-58-9) is reported to cause allergic reactions in humans. In addition, photosensitization induced by UV light have been observed (CICADS 62 (2004)). Based on this information, creosote oil is classified into Category 1. |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Classification is not possible due to lack of test results available. As relevant background information, regarding creosote oil (CAS No. 8001-58-9), both in-vivo micronucleus assay and DNA adduct tests gave positive results (CICAD 62 (2004), (ATSDR (2002)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | It is rated as "Cat. 2; R45" by the EU (2007). However, no animal test results supporting its carcinogenic effects could be identified. As relevant background information, creosote oil (CAS No. 8001-58-9), which is a different fraction of distillate from this substance, is rated as "Group 2A" by the IARC, "2A" by Japan Society for Occupational Health, "B1" by the EPA, and "Cat. 2" by the EU. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. As relevant background information, studies suggested an increased risk of brain cancer and neuroblastoma among offspring of male workers exposed to creosote oil (CAS No. 8001-58-9) (CICADS 62 (2004)). |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | No data available. Regarding creosote oil (CAS No. 8001-58-9), which is a different fraction of distillate from this substance, narcotic effects were noted in animal tests and respiratory tract irritation was seen in humans (CICAD 62 (2004)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. As relevant background information, in mist inhalation tests with creosote oil (CAS No. 8001-58-9), histiocytosis in the lung, increased weight of the liver and kidney (males), changes in the blood (decreased erythrocytes and hemoglobin, and increased reticulocytes) were noted (ATSDR (2002)). Thus, the lung, liver, kidney, and blood system are affected by creosote oil. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since its 48-h EC50 = 0.68 mg/L for crustaceans (Daphnia cucullata) (IUCLID, 2007), the substance was classified into Category 1 for acute toxicity. |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Its classification for acute toxicity is Category 1, it is readily biodegradable, and its potential for bioaccumulation is low (IUCLID, 2007). Based on this information, the substance was classified into the "Not classified" category. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |