GHS Classification Result

Chemical Name：Hydrazine sulfate
CAS：10034-93-2

Result：
ID: 93
Classifier: Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified: FY2007
Reference Manual: GHS Classification Manual （10 Feb, 2006）
Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - It contains chemical groups (hydrazine group) associated with explosive properties. Due to lack of test results, classification is not possible.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Classification not possible - - - - It contains chemical groups (hydrazine group) associated with explosive properties. Due to lack of test results, classification is not possible.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Since no information on salts of hydrazine is available, classification is not possible.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the oral LD50 of 418 mg/kg bw in mice administered with hydrazine sulfate (1:1) (CAS: 10034-93-2) (BUA 205, 1996), this substance was classified into Category 4.
1 Acute toxicity （Dermal） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since the substance is a solid, it was classified into the "Not applicable" category.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available.
2 Skin corrosion/irritation Classification not possible - - - - No data available. With regard to hydrazine sulfate (2:1) (CAS: 13464-80-7), no signs of irritation were detected in rabbits or humans treated with this substance (Hazard Assessment Report (NITE, CERI), 2004; BUA 205, 1996).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available.
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		No test results are available on salts of hydrazine. However, hydrazine (CAS: 302-01-2) has been classified into Category 1 for the reasons that it is known to induce allergic contact dermatitis (EHC 68, 1987) and classified as a skin sensitizing substance by Japan society for Occupational Health (Recommendations of Occupational Exposure Limits (2007)). Thus, we determined that hydrazine sulfate falls under Category 1 as well.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because both mouse spot tests (Hazard Assessment Report (NITE, CERI), 2004) and mouse micronucleus tests (Mutat Res., 389, 3-122, 1997) yielded positive results, the substance was classified into Category 2. According to reports on hydrazine (CAS: 302-01-2), a heritable mutagenicity test (dominant lethal test) gave negative results, no in vivo germ cell mutagenicity test was conducted, an an in vivo mutagenicity test using somatic cell (micronucleus test using mouse erythrocytes) gave positive results, and no in vivo genotoxicity test was conducted (Hazard Assessment Report (NITE, CERI), No.73 (2004); EHC 68, 1987). Based on this information, the substance was classified into Category 2.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		A salt of hydrazine is rated as "Carc. Cat. 2/R45" by the EU (2007). In addition, hydrazine/hydrazine sulfate are rated as "B2" by the U.S. EPA (1991) and "R" by the U.S. NTP (2005). Based on these ratings, the substance was classified into Category 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a hypodermal administration test in which pregnant rats were treated with hydrazine sulfate from day 11 to day 20 of gestation, the exposed dams showed a 20% decrease in body weight and 2 dams died. Reduced number of viable fetuses were found while no effects on numbers of implantation were noted by a Caesarean section performed on 9 dams on day 21 of gestation. The fetuses had reduced body weights and appeared pale and oedematous (neither body parts nor number of fetuses with these signs were given, presumably systemic in nature), but did not exhibit any major malformations. Based on this report, the substance was classified into Category 2. As additional background information, in a developmental toxicity test in which mice were treated with hydrazine (CAS: 302-01-2), excencephaly was seen in fetuses at doses that induced general toxicity. Thus, hydrazine is classified into Category 2.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, liver), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system, liver)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Classification of hydrazine salts is not possible due to insufficient test results available. With regard to the effects of hydrazine (CAS: 302-01-2), the following symptoms are reported in humans: confusion, lethargy, restlessness, unconsciousness, flushing, sporadic violent behavior and later developed ataxia, lateral nystagmus, decreased sense of vibration, paraesthesia in the arms and legs, elevated levels of AST, LDH, and total bilirubin (EHC 68 (1987)), and greatly elevated enzymatic values related to hepatic toxicity (Hazard Assessment Report (CERI, NITE) No. 73, 2003). These symptoms indicated that the nervous system and the liver are target organs. In addition, since lethargy was seen (EHC 68 (1987)), the substance presumably has narcotic effects and is classified into Category 3. Thus, this substance was classified into Category 1 for the nervous system and liver, and Category 3 for narcotic effects.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, liver, respiratory system, kidney, adrenal gland) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, liver, respiratory system, kidney, adrenal gland) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		In humans who ingested hydrazine sulfate three times a day for 1 to 6 months, vomiting, dizziness, excitation, insomnia, and polyneuritis syndrome were observed (ATSDR, 1997). In tests in which hamsters underwent forced oral administration for 15 to 20 weeks, cirrhosis, reticuloendothelial cell hyperplasia, and bile-duct proliferation were observed (Hazard Assessment Report (CERI, NITE), 2004). These reports indicated that the nervous system and liver are target organs. The effects seen in test animals were associated with doses that fall under the range of Category 1 guidance values. Regarding the effect of hydrazine (CAS: 302-01-2) on humans, the following were observed: jaundice, pneumonia, elevated creatinine levels, urine proteins, and bloody urine, focal hepatocellular necrosis, severe nephritis, necrosis of renal tubules, glomerulonephritis (Hazard Assessment Report (CERI, NITE), No. 73, 2003), pleural effusion and lung shadowing shown in X-ray examinations, elevated bilirubin levels in the blood, and pneumonia and hepatocellular damage revealed by autopsy (EHC 68, 1987). In treated animals, the following changes were observed: proliferation of the liver and bile-duct, degeneration of the adrenal gland, inflammation of the nasal mucosa, and necrosis, scaling, hyperplasia, and squamous cell metaplasia of the nasal epithelium (Hazard Assessment Report (CERI, NITE), No. 73, 2003). Based on these reports, we think hydrazine's target organs are the liver, respiratory system, kidney, and adrenal gland. All the effects seen in test animals were associated with doses that fall under the range of Category 1 guidance values. Based on the information above, this substance was classified into Category 1 (nervous system, liver, respiratory system, kidney, and adrenal gland).
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Using hydrazine (CAS 302-01-2), the 72-hour EC50 for algae (Selenastrum) is 0.006 mg/L (ECOTOX, 2007). Based on this information, the substance was classified into Category 1 for acute toxicity.
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Its classification for acute toxicity is Category 1, its potential for bioaccumulation is presumably low (log Kow = -2.07 (PHYSPROP Database, 2005), and it is not rapidly degradable (degradability measured as BOD for hydrazine: 2% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law)). Based on this information, the substance was classified into Category 1 for chronic toxicity.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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