Chemical Name:3,3'-Dichlorobenzidine dihydrochloride
CAS:612-83-9
ID: | 95 |
Classifier: | Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE) |
Year Classified: | FY2007 |
Reference Manual: |
GHS Classification Manual (10 Feb, 2006) Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Solid |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
7 | Flammable solids | Classification not possible | - | - | - | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | No data available. |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing no oxygen, fluorine or chlorine |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no bivalent -O-O- structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available. |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | In a study on 3,3'-dichlorobenzidine dihydrochloride (CAS: 612-83-9), the rat LD50 was 3.82 g/kg bw (ATSDR, 1999). Thus, the substance was classified into Category 5. |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Since the substance is a solid, it was classified into the "Not applicable" category. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | It is reported that no discernible skin irritation was observed when 3,3'-dichlorobenzidine dihydrochloride (CAS: 612-83-9) was applied to the skin of rabbits (ATSDR 1999). However, since no further information is available, the substance was classified into the "Classification not possible" category. |
3 | Serious eye damage/eye irritation | Category 1 | Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Application of 3,3'-dichlorobenzidine dihydrochloride (CAS: 612-83-9) into the eyes of rabbits caused strong eye irritation (erythema, pus, and corneal opacity) (ATSDR (1999)). Thus, the substance was classified into Category 1. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available. |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available. See also the classification of 3,3'-dichlorobenzidine (CAS: 91-94-1, NITE GHS classification ID 138). |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Application of 3,3'-dichlorobenzidine dihydrochloride in a reverse mutation test using Salmonella typhimurium, conducted as an in-vitro mutagenicity test, gave positive results (NTP DB, accessed in November 2007). However, since no appropriate in vivo test results are available, classification is not possible. See also the classification of 3,3'-dichlorobenzidine (CAS: 91-94-1, NITE GHS classification ID 138). |
6 | Carcinogenicity | Category 1B | Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Both 3,3'-dichlorobenzidine and 3,3'-dichlorobenzidine dihydrochloride are rated as "R" by the U.S. NTP (2005), and salts of 3,3'-dichlorobenzidine are rated as "Carc. Cat. 2" by the EU (2007). Based on these ratings, the substance was classified into Category 1B. | |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available. See also the classification of 3,3'-dichlorobenzidine (CAS: 91-94-1, NITE GHS classification ID 138). |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Classification not possible due to lack of data. See also the classification of 3,3'-dichlorobenzidine (CAS: 91-94-1, NITE GHS classification ID 138). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | No data available. See also the classification of 3,3'-dichlorobenzidine (CAS: 91-94-1, NITE GHS classification ID 138). |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available. See also the classification of 3,3'-dichlorobenzidine (CAS: 91-94-1, NITE GHS classification ID 138). |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
In a test on 3,3'-dichlorobenzidine dihydrochloride (CAS 612-83-9), the 96-hour LC50 for fish (Brachydanio rerio) was 3.3 mg/L (IUCLID, 2007). Thus, the substance was classified into Category 2 for acute toxicity. |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 | - | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Regarding 3,3'-dichlorobenzidine dihydrochloride (CAS 612-83-9), its classification for acute toxicity is Category 2, it is not rapidly degradable (BIOWIN, 2007), and BCF = 507 (IUCLID, 2007). Based on this information, the substance was classified into Category 2 for chronic toxicity. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
|
Definitions / Abbreviations |
|
Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |