NITE - Chemical Management Field

GHS Classification Result

Chemical Name：3,3'-Dimethylbenzidine dihydrochloride
CAS：612-82-8

Result：


ID:	97
Classifier:	Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE）
Year Classified:	FY2007
Reference Manual:	GHS Classification Manual （10 Feb, 2006） Technical Guidance Document on the GHS Classification （6 Dec, 2005）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	-	-	-	-	Solid
5	Gases under pressure	Not applicable	-	-	-	-	Solid
6	Flammable liquids	Not applicable	-	-	-	-	Solid
7	Flammable solids	Classification not possible	-	-	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid
10	Pyrophoric solids	Classification not possible	-	-	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing no oxygen, fluorine or chlorine
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no bivalent -O-O- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Since the substance is a solid, it was classified into the "Not applicable" category.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available.
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available.
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available.
4	Skin sensitization	Classification not possible	-	-	-	-	No data available. See also the classification of 3,3'-dimethylbenzidine (CAS: 119-93-7) (NITE GHS classification ID 148).
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Regarding in vitro mutagenicity tests using 3,3'-dimethylbenzidine dihydrochloride (CAS: 612-82-8), a reverse mutation test using Salmonella typhimurium and a chromosomal aberration test using CHO cells both gave positive results (NTP DB, accessed in November 2007). However, since no appropriate in vivo test results are available, classification is not possible. See also the classification of 3,3'-dimethylbenzidine (CAS: 119-93-7) (NITE GHS classification ID 148).
6	Carcinogenicity	Classification not possible	-	-	-	-	Salts of o-tolidine is rated as "Carc. Cat. 2" by the EU (2007). However, since details such as grounds for the rating are unclear, classification is not possible.
7	Reproductive toxicity	Classification not possible	-	-	-	-	In male rats given water containing 3,3'-dimethylbenzidine dihydrochloride (CAS: 612-82-8) an increased number of immature sperm was noted in the epididymis (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 4, 2005). However, since we are unable to determine if administration in fact impairs fertility based on the report, classification is not possible. See also the classification of 3,3'-dimethylbenzidine (CAS: 119-93-7) (NITE GHS classification ID 148).
8	Specific target organ toxicity - Single exposure	Category 3 （Respiratory tract irritation）		Warning	H335: May cause respiratory irritation (respiratory tract irritation)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	In humans, inhalation of small quantities of 3,3'-dimethylbenzidine dihydrochloride (CAS: 612-82-8) induced sneezing followed by upper respiratory tract irritation (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment), vol. 4, 2005). Thus, the substance was classified into Category 3 for respiratory tract irritation. See also the classification of 3,3'-dimethylbenzidine (CAS: 119-93-7) (NITE GHS classification ID 148).
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, kidney, lymph node, pancreas, thyroid, bone marrow)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, lymph node, pancreas, thyroid, bone marrow)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In the experiment in which rats were administered with 3,3'-dimethylbenzidine dihydrochloride (CAS: 612-82-8) in drinking water for 13 weeks, the following effects were observed in treated rats: hepatocellular necrosis, accumulation of bile pigments, increased severity of nephtopathy, lymphocytic atrophy of the thymus, lymphocytic atrophy of the mandibular and mesenteric lymph nodes, focal acinar cell degeneration in the pancreas, decreases in serum triiodothyronine (T3) values, decreases in thyroxin (T4) concentrations, and atrophy of the bone marrow in high dose groups (NTP TR 390, 1991). Thus, we determined that the liver, kidney, lymph node, pancreas, thyroid gland, and bone marrow are target organs. All symptoms were seen at doses that fall under Category 1. Therefore, 3,3'-dimethylbenzidine dihydrochloride was classified into Category 1 (liver, kidney, lymph node, pancreas, thyroid gland, and bone marrow) See also the classification of 3,3'-dimethylbenzidine (CAS: 119-93-7) (NITE GHS classification ID 148).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available. See also the classification of 3,3'-dimethylbenzidine (CAS: 119-93-7) (NITE GHS classification ID 148).

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Classification not possible	-	-	-	-	No data available.
11	Hazardous to the aquatic environment （Long-term）	Classification not possible	-	-	-	-	No data available.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）