Hazard class
|
Classification
|
Symbol
|
Signal word
|
Hazard statement
|
Precautionary statement
|
Rationale for the classification
|
1
|
Acute toxicity (Oral)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available. Regarding methacrylamide (CAS: 79-39-0), its rat LD50 = 1223 mg/kg bw (SIDS, 2005)
|
1
|
Acute toxicity (Dermal)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
1
|
Acute toxicity (Inhalation: Gases)
|
Not applicable
|
-
|
-
|
-
|
-
|
Solid
|
1
|
Acute toxicity (Inhalation: Vapours)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available. (Since no test results are available for each compound and mixture, we are unable to determine the state (solid, liquid or gas) of this mixture.)
|
1
|
Acute toxicity (Inhalation: Dusts and mists)
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available. (Since no test results are available for each compound and mixture, we are unable to determine the state (solid, liquid or gas) of this mixture.)
|
2
|
Skin corrosion/irritation
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available. As for methacrylamide (CAS: 79-39-0), no signs of skin irritation were observed in a study using rabbits (SIDS, 2005). However, based upon human experience it appears that acrylamide is a skin irritant (SIDS, 2005).
|
3
|
Serious eye damage/eye irritation
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available. As for methacrylamide (CAS: 79-39-0), it is moderately irritating to the eyes of rabbits (SIDS, 2005).
|
4
|
Respiratory sensitization
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
4
|
Skin sensitization
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|
5
|
Germ cell mutagenicity
|
Classification not possible
|
-
|
-
|
-
|
-
|
Regarding methacrylamide (CAS: 79-39-0), which is a component of the mixture, in vitro Ames test and chromosomal aberration test using CHL cells, as well as in vivo dominant lethal assay all gave negative results (SIDS, 2005). However, since we were unable to find a composition ratio of the mixture in these tests, classification is not possible.
|
6
|
Carcinogenicity
|
Classification not possible
|
-
|
-
|
-
|
-
|
The EU (2007) has rated the following mixture as "Carc. Cat. 2": a mixture of N-[3-hydoroxy-2-(2-methylacryloylamino-methoxy) propoxymethyl]-2-methylacrylamide; N-[2,3-Bis-(2-methylacryloyamino-methoxy) propoxymethyl]-2-methylamide; Methacrylamide; 2-Methyl-N-(2-methyl-acryloylaminomethoxymethyl)-acrylamide; and N-(2,3-Dihydroxypropoxymethyl)-2-methylacryl. However, since we were unable to find details such as grounds for the rating, classification is not possible.
|
7
|
Reproductive toxicity
|
Classification not possible
|
-
|
-
|
-
|
-
|
Regarding methacrylamide (CAS: 79-39-0), which is a component of the mixture, decreased viability of the pups was noted at doses that showed toxic effects on maternal animals in a preliminary reproduction toxicity screening test (SIDS, 2005). However, since we were unable to find a composition ratio of the mixture in these tests, classification is not possible.
|
8
|
Specific target organ toxicity - Single exposure
|
Classification not possible
|
-
|
-
|
-
|
-
|
Regarding methacrylamide (CAS: 79-39-0), which is a component of the mixture, adverse effects on the nervous system were noted in rats in a single dose oral administration test (SIDS, 2005). However, since we were unable to find a composition ratio of the mixture, classification is not possible.
|
9
|
Specific target organ toxicity - Repeated exposure
|
Classification not possible
|
-
|
-
|
-
|
-
|
Regarding methacrylamide (CAS: 79-39-0), which is a component of the mixture, effects on the nervous system were noted in rats and mice given this component in drinking water (SIDS, 2005). However, since we were unable to find a composition ratio of the mixture, classification is not possible.
|
10
|
Aspiration hazard
|
Classification not possible
|
-
|
-
|
-
|
-
|
No data available.
|