GHS Classification Result

Chemical Name:Mixture of N-[3-hydroxy-2-(2-methylacryloylaminomethoxy)propoxymethyl]-2-methylacrylamide, N-[2,3-bis-(2-methylacrylolyaminomethoxy)propoxymethyl]-2-methylamide, methacrylamide and 2-methyl-N-(2-methylacryloylaminomethoxymethyl)acrylamide
CAS:

Result:
ID: 100
Classifier: Ministry of Health, Labour and Welfare (MHLW), Ministry of the Environment (MOE)
Year Classified: FY2007
Reference Manual: GHS Classification Manual (10 Feb, 2006)
Technical Guidance Document on the GHS Classification (6 Dec, 2005)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products.
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - No data available.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - No data available.
11 Self-heating substances and mixtures Classification not possible - - - - No data available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data.
15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure
16 Corrosive to metals Classification not possible - - - - No data available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Classification not possible - - - - No data available. Regarding methacrylamide (CAS: 79-39-0), its rat LD50 = 1223 mg/kg bw (SIDS, 2005)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available. (Since no test results are available for each compound and mixture, we are unable to determine the state (solid, liquid or gas) of this mixture.)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available. (Since no test results are available for each compound and mixture, we are unable to determine the state (solid, liquid or gas) of this mixture.)
2 Skin corrosion/irritation Classification not possible - - - - No data available. As for methacrylamide (CAS: 79-39-0), no signs of skin irritation were observed in a study using rabbits (SIDS, 2005). However, based upon human experience it appears that acrylamide is a skin irritant (SIDS, 2005).
3 Serious eye damage/eye irritation Classification not possible - - - - No data available. As for methacrylamide (CAS: 79-39-0), it is moderately irritating to the eyes of rabbits (SIDS, 2005).
4 Respiratory sensitization Classification not possible - - - - No data available.
4 Skin sensitization Classification not possible - - - - No data available.
5 Germ cell mutagenicity Classification not possible - - - - Regarding methacrylamide (CAS: 79-39-0), which is a component of the mixture, in vitro Ames test and chromosomal aberration test using CHL cells, as well as in vivo dominant lethal assay all gave negative results (SIDS, 2005). However, since we were unable to find a composition ratio of the mixture in these tests, classification is not possible.
6 Carcinogenicity Classification not possible - - - - The EU (2007) has rated the following mixture as "Carc. Cat. 2": a mixture of N-[3-hydoroxy-2-(2-methylacryloylamino-methoxy) propoxymethyl]-2-methylacrylamide; N-[2,3-Bis-(2-methylacryloyamino-methoxy) propoxymethyl]-2-methylamide; Methacrylamide; 2-Methyl-N-(2-methyl-acryloylaminomethoxymethyl)-acrylamide; and N-(2,3-Dihydroxypropoxymethyl)-2-methylacryl. However, since we were unable to find details such as grounds for the rating, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Regarding methacrylamide (CAS: 79-39-0), which is a component of the mixture, decreased viability of the pups was noted at doses that showed toxic effects on maternal animals in a preliminary reproduction toxicity screening test (SIDS, 2005). However, since we were unable to find a composition ratio of the mixture in these tests, classification is not possible.
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Regarding methacrylamide (CAS: 79-39-0), which is a component of the mixture, adverse effects on the nervous system were noted in rats in a single dose oral administration test (SIDS, 2005). However, since we were unable to find a composition ratio of the mixture, classification is not possible.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Regarding methacrylamide (CAS: 79-39-0), which is a component of the mixture, effects on the nervous system were noted in rats and mice given this component in drinking water (SIDS, 2005). However, since we were unable to find a composition ratio of the mixture, classification is not possible.
10 Aspiration hazard Classification not possible - - - - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible - - - - Regarding methacrylamide (CAS: 79-39-0), its 96-hour LC50 for fish (medaka) is reported to be => 100 mg/kg (Ministry of the Environment, 2000). However, since we were unable to find a composition ratio of the mixture, classification is not possible.
11 Hazardous to the aquatic environment (Long-term) Classification not possible - - - - Its classification for acute toxicity is the "Classification not possible" category, and its solubility and ingredient composition are unavailable. Based on this information, classification is not possible.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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