GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：1-Amino-9,10-anthraquinone
CAS：82-45-1
Result：
| ID: | 1-019 |
| Classifier: | Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid |
| 7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature >650degC (IUCLID,2000)). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen. |
| 15 | Organic peroxides | Not applicable | - | - | - | - | The organic compound not including peroxy group in molecule. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Not classified | - | - | - | - | From LD50 value >5,000 mg/kg (OECD TG 401), and >1,600 mg/kg (SIDS (1996)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat, it was classified into "Not classified". |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | Based on description with LD50 value >2,000 mg/kg (SIDS (1996)) of the dermal administration test of mice, it was classified into "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Since there is a description, "There was no skin irritation in the 24-hour administration study using rabbits, "IUCLID (2000) and negative results have been obtained under stricter conditions than 4 hours, it was considered as "Not classified", but classification is not possible due to insufficiency of data, because there is no data to clearly deny toxicity in the information source of List 1. |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the result as "mild" eye irritation in the standard Draize test employing rabbits (SIDS (1996)), it was classified into Category 2B. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the result of negative in a body cell in vivo mutagenicity test (mouse micronucleus test) (SIDS (1996)), it was classified into "Not classified". |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification is not possible, because evaluation by major international evaluation institutions has not been performed and appropriate data are not available. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | In a combined repeated oral administration toxicity study and reproductive/developmental toxicity study (OECD TG 422, GLP) it is reported that "no effects on the rates of copulation, implantation, conception, delivery and natality or on the weight of the offspring were observed, and nor was any teratogenic action,"((Ministry of Health, Labor and Welfare Report (1994)) but it is also reported that female rats in the administration group "showed deterioration in their systemic symptom after they started rearing and the number of rats which abandoned rearing activities increased. Some reached a moribund state and some died, suggesting a strong causal relationship between commencement of rearing and onset of toxicity." Since this study was a simple test and there is no other data, classification is not possible. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney, spleen, blood system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (kidney, spleen, blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It is written in the combination test of repeated dose toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that "organic changes of the kidney" by exposure were observed, and "in the lien of administered group, pigmentation, extramedullary hematopoiesis and congestion significantly increased as compared with the control group, in addition, decrease in the number of red blood cells, hemoglobin content, hematocrit, and average red corpuscle hemoglobin concentrationan, and increase in reticulocyte ratio were found, therefore, it is thought that mild hemolytic anemia is caused" (Ministry of Health, Labour and Welfare reports (1994)). Since these effects were found within the scope of the guidance value of Category 2, it was classified into Category 2 (kidney, lien, and blood system). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 72 hours EbC50=0.25mg/L of the algae (Pseudokirchneriella subcapitata) (SIDS (2005)). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (1991))), it was classified into Category 1. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |