GHS Classification Result

Chemical Name：Anthracene
CAS：120-12-7

Result：
ID: 1-032
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 540degC (Lide,88th,2007)).
11 Self-heating substances and mixtures Classification not possible - - - - Classification not possible due to lack of data
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - From a description of LD50 value of 8,120 mg/kg (EU-RAR (2007)) in the oral administration test employing rats, it was classified into "Not classified".
1 Acute toxicity （Dermal） Not classified - - - - Since there was no mortality with test doses in the dermal administration test, it was written that LD50 value of rats was >1,320 mg/kg, and LD50 value of rabbits was >4,000 mg/kg (EU-RAR (2007)) . Based on the latest LD50 value with >4,000 mg/kg of rabbits tested to higher concentration, it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - In the 4th volume of MOE Risk Assessment (2005), it has been described that "the short term exposure slightly irritates the skin and causes redness of the skin" as an impact to humans. For animals, although it has been described that "fume may produce mild irritation on the skin" (EHC 202 (1998)), there was no description of "fume" in the cited literature (National Institute of Public Health and Environmental Protection (1989)) and experimental conditions could not be confirmed. Therefore, this data cannot be adopted. Moreover, although there is a description of "slightly irritating with Draize score of 0.79" (EU-RAR (2007)) in a 24-hour coating test employing rabbits (US Code of Federal Regulations), the result is from 10% solution. As mentioned above, classification is not possible with insufficient data.
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		"Congestion of a palpebral edema and a conjunctiva" (EU-RAR (2007)) is described about the impact to humans. It has been described that it has "non-irritant" (EU-RAR (2007)) for animals since "In the medication test to the conjunctival sac employing rabbits (US Code of Federal Regulations), there is no influence to cornea and iris, slight to moderate redness of conjunctiva was seen in 4/6 rabbits, and Draize score is 1.0. Moreover, there is also a description of "no cornea damage" (EU-RAR (2007)) in the dropping test to conjunctival sac employing a rabbit. According to Fig. 3.3.1 of the U.N. GHS second edition, it was classified into Category 2 employing the human data described in EU-RAR (2007) which is the information source of List1.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		There is a description of "negative" in the test examining contact sensitizing employing guinea pig (using adjuvant) (EU-RAR (2007)). On the other hand, it has been described that "skin sensitization to ultraviolet stimulation increased" in the test processing with this substance followed by ultraviolet exposure to hairless mice and guinea pig (EHC202 (1998)). Also for humans, there are two cases reporting that "redness, hives, or pomphus was observed" by ultraviolet irradiation after the skin application of the substance (the 4th volume of MOE risk assessment (2005)), and in one of them, it has been described that "redness was not observed in the control group only with ultraviolet irradiation" (the 4th volume of MOE risk assessment (2005)). Therefore, the substance was classified as Category 1 since it was presumed to indicate photosensitizing to human skin.
5 Germ cell mutagenicity Not classified - - - - Based on description of "negative" (EHC 202 (1998), EU-RAR (2007)) in the body cell in vivo mutagenicity test (micronucleus test employing each of the bone marrow and the red corpuscle of a mouse ), it was classified into "Not classified". The body cell in vivo genotoxicity test (SCE test employing the bone marrow of the Chinese hamster) is also "negative" (EU-RAR (2007)), and EHC 202 (1998) describes as "negative" as a whole except for some exceptions for the genetic toxicity of this substance.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is estimated the group 3 by IARC (IARC 32 (1983)) and the carcinogenicity classification D by EPA (IRIS (1991)), they are equivalent to "Not classified". However, after these evaluations by international evaluation organizations were done, the two-year oral administration test employing rats and mice was carried, which showed the increased incidence of tumors on liver of male rats and female mice, on bladder of male rats, and on kidney, bladder, womb, and mammary gland of female rats. Since there is a description that "positive carcinogenicityity was indicated" in male and female rats and female mice (Health, Labor and Welfare Ministry carcinogenicityity studies (1998)), based on this zoic tests data, it classified into Category 2. About humans, there is a description that "epithelioma was not produced" in workers who got in contact with the pure quality of this article (EU-RAR (2007)).
7 Reproductive toxicity Classification not possible - - - - There are descriptions as follows in the 90 day oral administration study using mice, " The average weight of ovaria and body weight ratios significantly increased statistically" but "There is no tissue change, " and "it is considered to be accidental, unrelated to toxicity."(EU-RAR (2007). Classification is not possible due to insufficiency of data, because there is no other appropriate datum with regard to reproductive developmental toxicity.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		As for humans, there are descriptions of "irritation of upper airway" and of "headache, nausea, delayed the response and debility" as acute symptoms by exposure (EU-RAR (2007)), and another description that "a respiratory tract is stimulated slightly and a cough and a pain in the throat appear" (the 4th volume (2005) of MOE risk assessment). However, it was not adopted as classified evidence since "headache, nausea, and reaction delay"cannot be regarded as material impacts. As for animals, it is described that "sprays exposure by this article stimulates an airway" (EHC 202 (1998)). As mentioned above, it classified into Category 3 (Respiratory tract irritation). In addition, the influence of congestion etc. at liver, lien and kidneys, etc. were looked in oral or dermal administration test using rats, mice, rabbit, etc. (EU-RAR (2007)), however, they were not adopted since the conditions in the concentration were well exceeding the guidance value of Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - It has been described that, in the forced oral administration test employing mice (GLP), "Significant affections due to exposure were not found in clinical symptoms, hematological findings, organ weight, macroscopic and histopathological manifestation, etc." at the concentration greatly exceeding the guidance value of Category 2. (EU-RAR (2007))Moreover, there is also a description that, in the mixed feed administration test employing rats, even if it was administered for 78 weeks at the concentration within the range of the guidance value of Category 2, "The affection on the clinical findings and tissues was not seen."(MOE Risk Assessment, Volume 4 (2005)). On the other hand, although there is a description of "Hemoglobin reduction, reticulocytosis, leukopenia, etc., were produced."(EU-RAR (2007)) in the aerosol inhalation exposure test employing rats, the exposure period is unknown (Original literature is not available.), and the classification cannot be specified. As mentioned above, classification is not possible due to insufficient data.
10 Aspiration hazard Classification not possible - - - - Classification is not possible because there is no data. In addition, although the substance is hydrocarbon, the kinematic viscosity is unknown. Moreover, there is no description about chemical pneumonia in ICSC.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LEC50=0.00278mg/L of the fish (Bluegill) (MOE Risk Assessment vol. 5 (2006)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 1.9% (standard test method (2 weeks)) (Existing Chemical Safety Inspections Data (1977))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information