GHS Classification Result

Chemical Name：Chloroalkane(C10-13)
CAS：85535-84-8

Result：
ID: 1-072
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - The flash point by IUCLID(2000), which has 49% or more of Cl content, is more than 166degC(closed type) it was classified into Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Classification not possible - - - - Classification not possible due to lack of data
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including chlorine, not fluorine and oxygen, this chlorine has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - In the oral administration test employing a rat, from the fact that there was no mortality at dose of 10,000 mg/kg (carbon number C10-13/chlorination rate (41- 50%, 51-60% or 61-70%)) and at dose of 13,600 mg/kg (carbon number C12/chlorination rate 60%) (EU-RAR (1999)), it was classified into "Not classified". In addition, EU-RAR (1999) indicates that the symptom and its extent are irrelevant to the chlorination rate.
1 Acute toxicity （Dermal） Not classified - - - - It was classified into "Not classified" from LD50 value 13,500 mg/kg (number of carbon: C12 / rate of chlorination: 59%) (EU-RAR (1999)) of the dermal administration test employing a rabbit.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - It is written that there is no mortality with 3.3 mg/L of 1-hour exposure amount in carbon number C12/ chloridization rate 59%, and there is no mortality with 48 mg/L of 1-hour exposure amount in carbon number C10-C13/ chloridization rate 50% in the inhalation exposure test (EU-RAR (1999)). Since saturated vapor pressure at 25degC is 0.000037-0.00014 mg/L (carbon number C10-C13/ chloridization rate 50%), the mist standard is applied. Since it was presumed that 4-hour equivalent LC50 values are >0.83 mg/L and >12 mg/L ,respectively, it was classified into "Not classified".
2 Skin corrosion/irritation Not classified - - - - There is an information that erythema and slight edema could be seen in rabbits but such symptoms disappeared (carbon number C10-13/chloridization rate 70%) within 7 days (EU-RAR (1999)). In this datum the score value for erythema of 2 out of 3 animals is 1 (maximum: 4) and the score value for edema of 2 out of 3 animals is 1 (maximum:4 until 24 hours after application). There is an information about humans beside them that although slight erythema and dry skin were observed, the effect (carbon number C10-12/ chloridization rate 5-% 63%) was corresponding to that of the control group or there was no symptom (carbon number C12/chloridization rate 59%), and there is an information about rabbits that there is no irritation (carbon number C10-13/chloridization rate 59%) (EU-RAR (1999)). It was classified into "Not classified" based on the above-mentioned.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Since EU-RAR (1999) has summarized that it is a mild irritation from the data of slight redness (59% of carbon number C12-/chlorination rate) and redness and conjunctiva dropsy being produced and continuing for 24 hours (carbon number: C10-13/chlorination rate: 63%, including an additive or stabilizer), and mild hyperaemia/ redness of conjunctiva (carbon number: C10-13/chlorination rate: 40%, 52%, including an additive or stabilizer) in rabbits, etc., it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data. It has been concluded that "although it has been widely used in industrially important substances despite no information on humans or animals, since there is no report indicating respiratory sensitization, it has no respiratory sensitization" in EU-RAR (1999).
4 Skin sensitization Not classified - - - - A conclusion in humans cannot be drawn from information of no allergic reaction in the human skin application (carbon number C12/ chlorination rate 59%) and of no positive reaction in cut refrigerant production workers (unknown carbon number and chlorination rate) (EU-RAR (1999)). On the other hand, it was classified into "Not classified" since it has been concluded in EU-RAR (1999) that there is no potential to produce sensitization from data of no skin reaction (carbon number C10-13/ chlorination rate 50%, including stabilizer) and no sensitization (carbon number C10-13/ chlorination rate 56%, incuding stabilizer) in guinea pig. In addition, it has been concluded that "although it has been widely used in industrially important substances despite no information on humans or animals, since there is no report indicating respiratory sensitization, it has no respiratory sensitization" in EU-RAR (1999)
5 Germ cell mutagenicity Not classified - - - - Since there was no change in lost number or position of live embryos, dead embryos, early absorbed embryos, and preimplantation embryos in a productive cell in vivo heritable mutagenicity test (dominant lethal tests employing a rat) (58% of carbon number C10-12/chlorination rate), and there was no increase in frequency of a chromosome aberration by the body cell in vivo mutagenicity test (chromosome aberration test employing rats bone marrow cell) (58% of carbon number C10-12/chlorination rate) (EU-RAR (1999), it was classified into "Not classified". It was negative in the reverse mutation test employing the bacterial (number of carbon: C12/chlorination rate: 57%, 60%, number of carbon: C10-13/chlorination rate: 50%) and in the gene mutation test employing Chinese hamster culture cells (number of carbon: C10-13/chlorination rate: 56%) (EU-RAR (1999)) in the in vitro.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Since it is classified in group 2B (IARC 48 (1990)) by IARC and in Cat. 3; R40 (EU-Annex I) by the European Union classification, it is taken as Category 2. In addition, although it does not match up with the CAS number (85535-84-8) of this article, "Chlorinated Paraffins (C12, 60% Chlorine)" (CAS 108171-26-2) is classifiied into R by NTP (NTP RoC 11th, 2005), and Chlorinated Paraffins is classified into 2B (Japan Society for Occupational Health society advice (2007)) in Japan Society for Occupational Health, which are all equivalent to Category 2 of GHS.
7 Reproductive toxicity Not classified - - - - According to EU-RAR (1999), while weight reduction of ovaria can be observed with the dose amount of 3,000mg/kg/day in the 14 day repeated oral administration study with rats (carbon number C10-12/chloridization rate 58%), no effect has been observed on male and female fertile capacities with the dose amount of 5,000mg/kg/day in the 13 week oral administration study (carbon number C12/chloridization rate 60%). Moreover, in the developmental toxicity study (carbon number C10-13/chloridization rate 58%) via oral administration using 25 pregnant rats in one group published in EU-RAR (1999) increase in the number of lost embryos after implantation and reduction in the number of live fetuses per mother animal have been observed with 2,000mg/kg/day where death (8 out of 25 animals), weakening, salivation and reduced activities of pregnant rats can be observed. There is a description as follows in AIST's Risk Assessment Documents 5 (2005), " The recognized reproductive toxicity is considered to be the secondary effect of the maternal toxicity and no effect on the development has been observed with the dose amount of 500mg/kg/day. Therefore, it was classified into "Not classified".
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From a description that inactivity and locomotor ataxia are seen in the oral administration test employing rats (EU-RAR (1999)) (number of carbon: C12/chlorination rate: 60%), it was classified into Category 3 (Narcotic effects).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - According to EU-RAR (1999), in a 90-day oral administration study in rats, weight increases in the liver and kidney and mild nephritis (carbon number C10-12/chlorination ratio 58%) in males were observed at 100 mg/kg. However, it was reported in EU-RAR (1999) that "the increase in liver weight reflects peroxisome proliferation, to which humans are not highly susceptible, so this is not relevant for human health," "it is uncertain if the effects on the kidney are toxicologically significant," and "the dosage at which other effects manifest themselves in rats is greater than 100 mg/kg." Using the reports in EU-RAR (1999), which are based on expert opinion, it was classified into "Not classified".
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 24 hours EC50=0.3mg/L of the crustacea (Daphnia magna) (EU-RAR (2000)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (EU-RAR (2000)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
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