GHS Classification Result

Chemical Name：1-Chloro-2-(chloromethyl)benzene
CAS：611-19-8

Result：
ID: 1-097
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Not classified - - - - Since the flash point by Merck KGaA data from March 2009 is 109degC, it was classified into Not classified.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point >600degC (Merck KGaA data from March 2009)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including chlorine, not fluorine and oxygen, this chlorine has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was classified into Category 4 from LD50 value of 951 mg/kg (male), 783 mg/kg (female) (Health, Labor and Welfare Ministry report (Access on September 2008)), and low value of 783 mg/kg (SIDS (2004)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		The lower value 1,700 mg/kg was taken from LD50 value 1,700 mg/kg (male) and 2,200 mg/kg (female) (SIDS (2004)) of the dermal administration test employing a rabbit (FIFRA Pesticide Assessment Guidelines, GLP), and it was classified into Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Saturated vapor pressure level of this substance at 25degC is 1.3 mg/L (197 ppm) . Since LC50 value of the 1-hour vapor inhalation exposure test employing rats (Equivalent to OECD 403, GLP) is >1.14 mg/L (equivalent >173 ppm) (SIDS (2004)), the gas standard is applied. 4-hour equivalent LC50 value is >87 ppm, and since classification cannot be specified, classification is not possible.
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Since LC50 value of 4-hour aerosol inhalation exposure test employing rats (OECD TG 403, GLP)is 2.8 mg/L (SIDS (2004)), it was classified into Category 4.
2 Skin corrosion/irritation Not classified - - - - Although it seems to be classified into skin irritation Category 3 in the U.N. GHS from description of "mild skin irritation with less than score 2 in all three rabbits by application for four hours" (SIDS (2004)) in the skin irritation and corrosion test with rabbits (OECD TG 404, GLP), it was classified into "Not classified" because of unemployed category in the country.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		"When it was dropped into the eyes of three rabbits and the eyes were washed 24 hours after and were observed for 14 days in the eye irritation/corrosion test employing rabbits (OECD TG 405, GLP), all eyes showed mild/moderate eye irritation. From the description of " The conjunctival effect survived in one rabbit after seven days but it disappeared after 14 days."(SIDS (2004)), it was classified into Category 2A.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Since it has been concluded that "although there is a data in 1936 that 8 of 13 guinea pig were positive, since the standard of judgment is not clear, it is not reliable" (SIDS (2004)), classification is not possible.
5 Germ cell mutagenicity Not classified - - - - It was classified into "Not classified" based on the statement that the body cell in vivo mutagenicity test (micronucleus tests which employs rat erythrocytes) (OECD TG 474, GLP) was "negative" (SIDS (2004)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - There is a report of "effects on reproductive capacity and offspring at doses at which hyperplasia of anterior gastric wall and squamous epithelium, erosion and ulcers in females and decreased weight gain and feed intake in males and females were observed" in a combined repeated dose toxicity study and reproductive/developmental toxicity screening study using oral administration in rats (OECD TG 422, GLP) (Ministry of Health, Labor and Welfare Report (Access on September 2008), SIDS (2004)). Since this study was a simple test, however, and there is no other data, classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects, Respiratory tract irritation） Warning H335: May cause respiratory irritation (narcotic effects, respiratory tract irritation)
H336: May cause drowsiness or dizziness (narcotic effects, respiratory tract irritation) 		P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From descriptions of "The gait abnormality and locomotor activity reduction have been seen in the living animals" in the acute oral toxicity test employing rats (OECD TG 401, GLP) (Health, Labor and Welfare Ministry reports (Access on September 2008)) and "respiratory ability reduction and sensory irritation" (SIDS (2004)) in the inhalation exposure test employing mice, it was classified into Category 3 (Narcotic effects, Respiratory tract irritation).
9 Specific target organ toxicity - Repeated exposure Category 1 (stomach, respiratory system, hematopoietic system) Danger H372: Cause damage to organs through prolonged or repeated exposure (stomach, respiratory system, hematopoietic system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is written in the combination test of repeated oral toxicity study and reproduction screening study in rats (OECD TG 422, GLP) that there were hyperplasia of anterior gastric wall, increased flat epithelium, erosion, and ulceration in females, and hyaline droplet hyperpigmentation in proximal tubular epithelium of the kidney in males (Ministry of Health, Labour and Welfare reports (Access on September 2008), SIDS (2004)). On the other hand, it is written in repeated inhalation exposure test in rats (OECD TG 412, GLP) that "there were damage to nasal mucosa, trachea, and bronchi, and increase in bone marrow cells and erythrocytic cells" (SIDS (2004)). Effects on stomach, respiratory system, and blood system were found within the scope of the guidance value of Category 1. Since the kidney symptom can be said to be specific to male rats, it is not adopted. Therefore, it was classified into Category 1 (stomach, respiratory system, and blood system).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.27mg/L of the fish (Oryzias Latipes) (Environmental Agency eco-toxicity tests of chemicals (1998)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (standard test method (4 weeks)) (Existing Chemical Safety Inspections Data (2001))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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