GHS Classification Result

Chemical Name:2-Chlorophenol
CAS:95-57-8

Result:
ID: 1-120
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Since the flash point by HSDB(2005) is 64degC(closed type), it was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point 550degC (Merck KGaA data from March 2009)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including oxygen and chlorine, not fluorine, these oxygen and chlorine have not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
There is description of LD50 value of 40 mg/kg and 670 mg/kg of the acute oral toxicity test employing a rat (6th volume (2008) of MOE risk assessment), with about 2,000 mg/kg (OECD TG 401, GLP) (Health, Labor and Welfare Ministry reports (Access on October 2008)). Since LD50 value of 2,000 mg/kg of OECD TG 401 and GLP based standard test falls within Category 4, and there exists much data in Category 4, it was classified into Category 4.
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Since it was described as LD50 value 1,000-1,580 mg/kg (ATSDR (1999)) of the dermal administration test employing a rabbit, it was classified into Category 4. In addition, although it was described that LD50 value of the dermal administration test employing a rabbit was 740-2,670 mg/kg (HSDB (2005)), since it was the description about Phenol rather than this substance as a result of checking the primary reference (Toxicol.Appl.Pharmacol.42 (1977)), it is not adopted.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a liquid on the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
It is written that LC50 value of 4-hour inhalation exposure test employing rats (OECD TG 403) is 2.05 mg/L (equivalent 390 ppm) (IUCLID (2000)). Since saturated vapor pressure level of this substance (20degC) is 2,270 ppm, it was classified into Category 2 by applying the gas standard. It is written in ATSDR (1999) that there was no mortality with 908 ppm in 4-hour inhalation exposure test employing rats.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Category 1 Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
For animals, "corrosion with severe skin damages such as erythema, dropsy, discoloration, etc."(ATSDR (1999)) has been described in the direct dosage study to skin of rabbits. For humans, "concern about occurrence of contact dermatitis" (HSDB (2005)) has been described. Therefore, it was classified into Category 1.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
It was classified as Category 1 based on descriptions that it is a skin corrosive substance and "strongly irritates eyes and causes redness, pain, and haze eyes when going into eyes" (the 6th volume of the MOE Risk Assessment (2008)), and that it is "corrosive" to eyes of rabbits (ATSDR (1999)).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data. In addition, there is a description of "concern about contact dermatitis" in humans (HSDB (2005)).
5 Germ cell mutagenicity Not classified - - - - Based on description of "negative" (IUCLID (2000)), in the body cell in vivo mutagenicity test (micronucleus tests employing a mouse), it was classified into "Not classified". It has been described that the body cell in vivo genotoxicity test (SCE test employing the mouse bone marrow cell) is "negative" (ATSDR (1999)) while the in vitro mutagenicity test (chromosome aberration test employing Chinese hamster culture cells (OECD TG 473, GLP)) is "positive" (Health, Labor and Welfare Ministry reports (Access on October 2008)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made, classification is not possible. In addition, it is described that "there is a tumor promotions effect", but "there is no proof that it has an effect of initiation" in the test employing mice or rats (EHC 93 (1989)).
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since it is described as follows in the drinking water administration study using rats, " Decrease in the number of fetuses per one litter and increase in the number of still birth of fetal animals were observed" (MOE Risk Assessment Vol.6 (2008) and there is a description as follows in the primary literature (Environ. Health Perspect. 46 (1982)), "There is no effect on the body weight increase and blood index such as the number of red blood cells, " it was classified in Category 1B. There is a description as follows in the drinking water administration study using rats, "No teratogenicity was found" (EHC 93 (1989)).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, central nervous system) Danger H370: Causes damage to organs (respiratory system, central nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
As for humans, the 6th volume (2008) of the MOE Risk Assessment which is the information sources of List1 has a description that "it strongly stimulates a respiratory tract, and causes a sense of exhaustion, a deep sleep, a spasm, inhalation then cough, shortness of breath, sore throats, etc. when oral ingestion is carried out. Lung edemas may be caused when an aerosol is inhaled," and HSDB (2005) which is the information source of List2 have a description of "the influence on a central nervous system, and lung dropsy" by acute exposures. Moreover, the inhalation exposure test employing rats (OECD TG403) showed "gross change of lung tissue" (IUCLID (2000)) within the limits of the guidance value of Category 1. As mentioned above, it was classified into Category 1 (the respiratory systems, central nervous systems).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Although in repeated oral administration test in rats "high level of liver weight, hypertrophy of hepatocytes, tremulousness, decrease in locomotor activity, and gait abnormality " (Ministry of Health, Labour and Welfare reports (Access on October 2008)) were found, they are effects out of the scope of the guidance value of Category 2. It is written in oral study in mice that "decrease in liver, lien and brain weight "was found, however, "there were no abnormality in morphology or organization" (ATSDR (1999)). Since there is no examination data based on other exposure paths, classification is not possible.
10 Aspiration hazard Classification not possible - - - - Although the kinematic viscosity at 40degC is expected to be 14 mm2/s or less, the classification is not possible since the substance is not hydrocarbon.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 48 hours EC50=3.9mg/L of the crustacea (Daphnia magna) (Hazard Assessment Report (2008)).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no rapid degradability (the decomposition by BOD: 0%(standard test method (2 weeks)) Existing Chemical Safety Inspections Data (1980))), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

MHLW Website (in Japanese Only)


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