GHS Classification Result

Chemical Name：4-Chloro-3-methylphenol
CAS：59-50-7

Result：
ID: 1-129
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 590degC (ICSC,1997)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including oxygen and chlorine, not fluorine, these oxygen and chlorine have not chemically bound to any elements other than carbon and hydrogen.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Although it is corrosive to metals (HSDB,2003), test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was classified into Category 4 from minimum value 1,830 mg/kg among LD50 value 5,129 mg/kg , 3,636 mg/kg, and 1,830 mg/kg (DFGOT vol.2 (1991)) of the oral administration test employing a rat. In EU classification, Xn; R21/22 (EU-Annex I).
1 Acute toxicity （Dermal） Not classified - - - - From LD50 value >5,000 mg/kg (IUCLID (2000)) of the dermal administration test employing a rabbit, it classified into "Not classified". In EU classification, Xn; R21/22 (EU-Annex I).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Since there was no mortality with highest dose 0.704 mg/L in the dust inhalation exposure test employing rats (4 hours) (DFGOT vol.2 (1991)), LC50 value is considered to be >0.704 mg/L, however, classification is not possible since classification cannot be specified.
2 Skin corrosion/irritation Classification not possible - - - - There is a description, "no skin irritation" (IUCLID (2000)) in the skin irritation/corrosion test with rabbits (OECD TG 404) and in the 24 hour study to administer 2000mg/kg to rats. On the other hand, there are descriptions, "moderately irritating" (IUCLID (2000) in the 4 hour administration study applied to the injured /uninjured shaven skin of rabbits and that of "corrosion" (IUCLID (2000) in the 24 hour study to administer sodium salt of this substance to rabbits. Based on the above-mentioned, classification is not possible.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Since there is a description of "remarkable redness and swelling of the conjunctiva and iris, and corneal opacity were seen also on the 7th day " (DFGOT vol.2 (1991)) in the test employing rabbits and also in HSDB (2003), in the test using rabbits, it is described as "Application of 0.05% solution to the eye causes corneal opacity." , and "The corrosion of a cornea, the inflammation of a conjunctiva, an ulcer, iritis, etc. are produced, and they are irreversible for 21 days" , it was classified into Category 1. EU classification is Xi; R41 (EU-Annex I).
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		For humans, it has been reported that "positive cases were not observed," however, "0.2-3% of patients showed a sensitizing potential to the substance" in the patch test using a 5% solution in 31 healthy persons and in the patch test using a 20% solution in 66 healthy persons (DFGOT vol.2 (1991)). For laboratory animals, a positive reaction has been described in several tests. For example, "mild redness" was observed in half or more animals in the Maximization tests with 15 guinea pig (DFGOT vol.2 (1991)). As mentioned above, it was classified into Category 1. It can be classified as R43 (EU-Annex I) in the European Union classification and displayed as Sh (ACGIH-TLV/BEI (2005)) in the German MAK list.
5 Germ cell mutagenicity Not classified - - - - Based on the description of "negative" in the body cell in vivo mutagenicity test (micronucleus tests which employed mouse erythrocyte) (HSDB (2003)), it was classified into "Not classified". There is also a description that it was "negative" in UDS test employing the rat hepatocytes in vitro, in the forward mutations (HGPRT) examination employing a CHO cell, and in the reverse mutation test employing a Salmonella typhimurium (HSDB (2003)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Although it is reported that there are no effects on pregnancy rates and fetuses at doses at which "dyspnea and significantly decreased weight gain are observed" (HSDB (2003), IUCLID (2000)) in mother animals in a prenatal developmental toxicity study in rats (OECD TG 414, GLP), there is no data concerning effects on the reproductive functions, so classification is not possible.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		From descriptions of "Temporary irritation to nasal, mucous membrane" (DFGOT vol.2 (1991)) and of "Respiratory tract irritation" (ICSC (1997)) in the rat which was inhaled and exposed to powder dust, it was was classified into Category 3 (Respiratory tract irritation). In addition, for humans, although the case of expressing "left facial numbness" after being exposed to this substance is reported in HSDB (2003), it is only one case, and since it cannot be judged whether it is the consistent effect, it was not adopted. About an animal, although there is description of the effect "the mitochondria of liver, the increase in a small granule vesicle, change of a granular endoplasmic reticulum, enlargement of a bile capillary, etc. are seen" (HSDB (2003)), by the rat by which single time oral administration was carried out, since it is not considered a material impacts, 400 mg/kg is not adopted.
9 Specific target organ toxicity - Repeated exposure Category 2 (brain, kidney, liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (brain, kidney, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There has been reports of "weight increase of kidney and histopathological changes (kidney papillary necrosis in male rats, kidney cortical enlargement, fibrillization), change of cerebral weight, and histopathological changes" (HSDB (2003)) in the group administered with more than 21.0 mg/kg or more in 24 months mixed feed administration test employing rats and of "pericholangitis of liver and bile duct proliferation " in 160 mg/kg (90 days corresponding value: 26.7 mg/kg) administered group in 21 days dermal administration test employing rabbits (15 times administer), (HSDB (2003)). As mentioned above, it was classified into Category 2 (brain, kidney, liver).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.917mg/L of the fish (Rainbow Trout) (AQUIRE (2008)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (the decomposition by BOD: 0%(standard test method (4 weeks)) Existing Chemical Safety Inspections Data (1983))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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