GHS Classification Result

Chemical Name:N-(Cyclohexan-1-ylsulfanyl)phthalimide
CAS:17796-82-6

Result:
ID: 1-155
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - Although it is an organic compound including oxygen, not fluorine and chlorine, this oxygen has not chemically bound to any elements other than carbon and hydrogen.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Although there are descriptions of LD50 value 2,600 mg/kg (IUCLID and (2000)), HSDB (2005), and 4,600 mg/kg, 8,200 mg/kg (IUCLID (2000)), etc., of the oral administration test employing a rat and the minimum value of 2,600 mg/kg corresponded to the U.N. GHS acute toxicity category 5, they fell under unadopted category in Japan and were classified into "Not classified".
1 Acute toxicity (Dermal) Not classified - - - - From a description of LD50 value of >5,010 mg/kg (IUCLID (2000), HSDB (2005)), >2,510 mg/kg, and >7,940 mg/kg (IUCLID (2000)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Not classified - - - - Since there are descriptions, "not irritating, PII:1.7/8" (IUCLID (2000)) and "not irritating, PII:1.2/8" (IUCLID (2000)) in the Draize test with rabbits, it was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2 Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Although there are descriptions of "irritating, Draize score: 48/110" (IUCLID (2000)), "irritating, Draize score: 35/110" (IUCLID (2000)), "Mildly irritating. Draize score: 22.3-24.6/110" (HSDB (2005)), and of "not irritating" (IUCLID (2000)) in the Draize test employing rabbits, since there was much data equivalent to Category 2, it was classified into Category 2.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
It was classified as Category 1 from descriptions of "sensitizing" in the human patch tests (IUCLID (2000)), and that "allergic reaction to humans was observed" (HSDB (2005)).
5 Germ cell mutagenicity Not classified - - - - Since there are descriptions that the body cell in vivo mutagenicity test (chromosome aberration test employing a rat) was "negative" (HSDB (2005)), and in vitro mutagenicity test (the Ames examination, mouse lymphoma assay employing a Salmonella typhimurium) was "negative" (IUCLID (2000), HSDB (2005)), it classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Classification is not possible due to insufficiency of data, because evaluation by major international evaluation institutions has not been performed. Incidentally, there is a description of 24 months mixed-food study in HSDB (PRL Protocol, GLP) using rats , and when the cited literature was reviewed, a description was found as follows, " It will not cause carcinogenicity actions against human health."(USCh (2003)).
7 Reproductive toxicity Not classified - - - - Based on the fact that no reproductive toxicity was found (IUCLID (2000), HSDB (2005)) in the 2 generation reproductive toxicity study (Bio/dynamics Laboratory method, GLP) and teratogenicity was not observed at the dose level (IUCLID (2000)) where the body weight reduction was found among mother animals in the teratogenicity study using rabbits (Bio/dynamics Laboratory method, GLP), it was classified into "Not classified".
8 Specific target organ toxicity - Single exposure Not classified - - - - From the description of "Although hypoactivity and the appetite loss were seen in clinical observation, all organs were normal as a result of necropsy" in the test at up to dose 3,160 mg/kg in the oral administration test employing rats (HSDB (2005)), .it was classified into "Not classified".
9 Specific target organ toxicity - Repeated exposure Category 2 (lung) Warning H373: May cause damage to organs through prolonged or repeated exposure (lung) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
When checking the cited reference (USCh (2003)) in 28-day oral administration test in rats (PRL Protocol, GLP) (IUCLID (2000), HSDB (2005)), it is written in the scope of the guidance value of Category 2 that" weight loss was found, however, it had no effects on blood finding, organ weight, and autopsy results". On the other hand, since "the Rassel sound of lungs and the disseminated granuloma"(HSDB (2005))) were found within the scope of the guidance value of Category 2 in 90- day inhalation exposure test in rats (Bio/dynamics Protocol, GLP), it was classified into Category 2 ( lungs ).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours EC50=0.41mg/L of the fish (Rainbow Trout) (IUCLID (2004)).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and there were no rapid degradability (BIOWIN7), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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