GHS Classification Result

Chemical Name：2,4-Dichlorotoluene
CAS：95-73-8

Result：
ID: 1-165
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Liquid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid
5 Gases under pressure Not applicable - - - - Liquid
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. ? No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		Since the flash point by HSDB(2003) is 93degC(open type), it was classified into Category 4.
7 Flammable solids Not applicable - - - - Liquid
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition point >450degC (Merck KGaA data from March 2009)).
10 Pyrophoric solids Not applicable - - - - Liquid
11 Self-heating substances and mixtures Classification not possible - - - - The test method suitable for liquid substances is not established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Although it is an organic compound including chlorine, not fluorine and oxygen, this chlorine has not chemically bound to any elements other than carbon and hydrogen.
14 Oxidizing solids Not applicable - - - - Liquid
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - LD50 value 2,790 mg/kg of the oral administration test employing a rat (SIDS (1995)), which corresponded to the U.N. GHS acute toxicity Category 5, fell under unadopted category in Japan and was classified into "Not classified".
1 Acute toxicity （Dermal） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Not classified - - - - LC50 value of the 4-hour inhalation exposure test employing rats is >2,669 mg/L (SIDS (1995)). Since this value was larger than saturated vapor pressure level with 3.9 mg/L (25degC), it was classified into "Not classified" by applying the mist standard.
2 Skin corrosion/irritation Classification not possible - - - - GESTIS (Access on October 2008) classifies it as Xi; R38. Although this corresponds to GHS Category 2-3, classification is not possible because data are insufficient. There is a description that an isomer composite, Diethyltoluene has possibility to have irritation (HSDB (2003)).
3 Serious eye damage/eye irritation Classification not possible - - - - Although ther is a description of severe irritation to 4-Chlorotoluene of analog (HSDB (2003)), classification is not possible because of insufficient data as this substance.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Classification is not possible since there is no data.
5 Germ cell mutagenicity Classification not possible - - - - Although there is a description of "Both are negative" in the in vitro mutagenicity test (the mutagenicity test employing a Salmonella typhimurium, the chromosome aberration test employing Chinese hamster culture cells) (Health, Labor and Welfare Ministry reports (Access on September 2008)), classification is not possible because there is no data of in vivo examination.
6 Carcinogenicity Classification not possible - - - - Classification is not possible, because evaluation by major international evaluation institutions has not been performed and no datum is available.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In a combined repeated dose toxicity study and reproductive/developmental toxicity screening study in rats (OECD TG 422), reduced conception rates and lower offspring weight were confirmed at a dose at which toxic effects (liver, kidney) were observed in mother animals (500 mg/kg) (Ministry of Health, Labor and Welfare Report (Access on September 2008)), so it was classified as Category 2.
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The single-dose oral study of rats has a description that "the effect by administration of test article was not deemed but diminished spontaneous activity and staggering gaits were foreseen" in the necropsy and histopathological examinations (Health, Labor and Welfare Ministry reports (Access on September 2008)), and another description that "procumbent, tremor, decay, motor ataxia, labored breathing, the blood lump of the nasal cavity circumference, the urinary stain, etc. were foreseen" in the single-dose forcible oral administration study of male rats (HSDB (2003)). Furthermore, as for human accidents cases, the 2007 Health, Labor and Welfare Ministry home page (http://www.mhlw.go.jp/bunya/roudoukijun/anzeneisei10/12.html) has a description that "Since an automatics scales did not operate appropriately during the work to fill up drum cans with the drug, 2,4-dichlorotoluene began to leak from gaps of inlets of filling nozzle of drum can, and while wiping the leaked 2,4-dichlorotoluene with a rag, the worker inhaled 2,4-dichlorotoluene steam of this rag and became poisoned. "As mentioned above, it was classified into Category 3 (Narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is written in 46-day repeated dose toxicity/reproduction combination test in rats (OECD TG 422) that "there were centrolobular hypertrophy of hepatocytes, atrophy and reproduction of tubular epithelium, and extension of tubular" (Ministry of Health, Labour and Welfare reports (Access on September 2008). Since these effects were found within the scope of the guidance value of Category 2, it was classified into Category 2 (liver, kidney).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=2.7mg/L of the fish (Oryzias Latipes) (SIDS (1995)).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (Existing Chemical Safety Inspections Data (1995)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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