GHS Classification Result

Chemical Name:1,2-Dichloro-4-nitrobenzene
CAS:99-54-7

Result:
ID: 1-166
Classifier: Ministry of Economy, Trade and Industry (METI), Ministry of the Environment (MOE)
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government (Sep, 2008)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Although the nitro group is included in chemical structure and the calculation value of oxygen balance is -96, it was classified into Not classified since it was classified into Class 6.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1578(ICSC, 1995)).
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not classified - - - - Although the nitro is included in chemical structure, it was classified into Not classified, since it was classified into Class 6.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1578(ICSC, 1995)) .
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 420degC (IUCLID,2000)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Classification not possible - - - - Although it is an organic compound including oxygen having chemically bound to elements other than carbon and hydrogen, classification is not possible due to lack of data.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
From a description of 625 mg/kg of lower value among LD50 value of 625 mg/kg and 800 mg/kg (SIDS (2003)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity (Dermal) Not classified - - - - Since LD50 value of the dermal administration test employing rats was >2,000 mg/kg (SIDS (2003)), it was classified into "Not classified".
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Not classified - - - - Since the 24 hour skin irritation/corrosion test with rabbits (OECD TG 404, GLP) did not identify skin irritation (average scored values for erythema/crust and edema:0.2, 0.0) (SIDS (2003)), it was classified into "Not classified".
3 Serious eye damage/eye irritation Not classified - - - - From a description of "slightly irritating (the mean score values of corneal opacity / iritis / conjunctival redness / conjunctival edemas: 0/0.1/1.3/0.2) and it recovered in 72 hours" in the eye irritation/corrosion test (SIDS (2003)) employing rabbits (OECD TG 405, GLP), it was classified into "Not classified".
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Not classified - - - - It was classified into "Not classified" from descriptions that skin sensitization was not shown in the Maximization tests employing 20 guinea pig (OECD TG 406, GLP) and that skin sensitization was not shown in the test of eczema-like contact dermatitis in ten women (SIDS (2003)).
5 Germ cell mutagenicity Not classified - - - - From the description that the body cell in vivo mutagenicity test (chromosome aberration test employing a rat bone marrow cell (GLP)) which used the commercial grade (85% of this substance and 15% of 1,2-dichloro-3-nitrobenzene) is negative and there is no proof of in vivo heredity toxicity in the dosage which does not show general toxicity (SIDS (2003)), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Although it is 3B by German DFG classification (ACGIH (7th, 2001)), classification is not possible since no evaluation of other major international evaluation agencies such as IARC is made.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
There is a description in the 20 day oral administration study using rats (OECD TG 407) that no effect was caused against male and female reproductive functions (SIDS (2003)). Since it is described that ureteral dilatations were observed in fetuses at the dose level of 30mg/kg where suppression of the body weight increase is found among mother animals in the developmental toxicity study (GLP), while a product of commercial grade (85% of this substance and 155 of 1,2-dichloro-3- nitrobenzene) was orally administered to rats for 6-15 days of pregnancy, it was classified in Category 2. Incidentally, It is described that no clear effect was recognized on the reproduction by parent animals and development of fetal animals even with the administration of the maxumum dose level of 100mg/kg with regard to 1,2-dichloro-3- nitrobenzene (Access on October 2008).
8 Specific target organ toxicity - Single exposure Category 3 (Narcotic effects) Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into Category 3 (Narcotic effects) based on a description that inactivity, atrophy, and a coma were seen in the oral administration test of rats, and temporary inactivity is seen in dermal administration test of rabbits (SIDS (2003)).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system, liver, kidney), Category 2 (spleen) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (blood system, liver, kidney)
H373: May cause damage to organs through prolonged or repeated exposure (spleen)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
In 4-month vapor inhalation exposure test in rats and mice (4 hours/day), increase in methemoglobin and Heinz body, decrease in the number of red blood cells and hemoglobin, and decrease in serum transaminase and liver catalase, etc. are described (SIDS (2003)). Moreover, it is written in 28-day oral administration test in rats (OECD TG 407, GLP) that there were increase in urea value, decrease in the number of red blood cells, drop in hematocrit, increase in relative liver weight, increase in MCV value, increase in reticulocyte, increase in lien weight, lien congestion, splenic extramedullary hematopoiesis, and hemosiderosis (SIDS (2003)). Since effects on the blood system, liver, kidney are found within the scope of the guidance value of Category 1, and effects on lien are found within the scope of the guidance value of Category 2, it was classified into Category 1 (blood system, liver, and kidney) and Category 2 (lien).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 72 hours EC50=2.5mg/L of the algae (Pseudokirchneriella subcapitata) (MOE eco-toxicity tests of chemicals (2004)).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 2 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 0% (Existing Chemical Safety Inspections Data (1985)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


To GHS Information