GHS Classification Result

Chemical Name：Sodium dimethyldithiocarbamate
CAS：128-04-1

Result：
ID: 1-220-1）
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		From a description of LD50 value of 1,000 mg/kg (IUCLID (2000), HSDB (2005)) in the oral administration test employing rats, it was classified into Category 4.
1 Acute toxicity （Dermal） Not classified - - - - Since LD50 value of the dermal administration test employing rats was >5,000 mg/kg (IUCLID (2000)), it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Classification not possible - - - - Classification not possible due to lack of data
3 Serious eye damage/eye irritation Classification not possible - - - - Although there is a description of "not irritating" (IUCLID (2000)) in the eye irritation test employing rabbits (OECD TG405), since it is a non-GLP test and there is no other data, classification is not possible.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Classification not possible - - - - Although there is a description of "not sensitizing" in the Maximization test employing guinea pig (IUCLID (2000)), classification is not possible because of unknown OECD TG conformity, non-GLP test, and no other data.
5 Germ cell mutagenicity Classification not possible - - - - Classification is not possible because there is no data of in vivo examination.In addition, there are descriptions of "negative" in the HGPRT tests employing the CHO culture cells (IUCLID (2000)) and "positive" in the Ames test employing a Salmonella typhimurium as in vitro examinations (IUCLID (2000)).
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible.
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 1／2 (nervous system, systemic toxicity) Danger H370: Causes damage to organs (nervous system, systemic toxicity) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		The test employing rabbits has a description of "reduction of central nervous system control, a tactile sense, and algesia susceptibility, internal-organs congestion, accumulation of fluid in the lungs, localized hemorrhages of gastric mucous membrane, and description of bowel swelling" (HSDB (2005)), and since these were seen within the limits of the guidance value of Category 1 or Category 2, they were taken as Category 1/2 (nervous systems, systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Category 2 (nervous system, systemic toxicity) Warning H373: May cause damage to organs through prolonged or repeated exposure (nervous system, systemic toxicity) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the report that "myasthenia, changes in blood morphology and the nervous and cardiovascular systems were observed at a dose of 100 mg/kg" (HSDB (2005)) in a 15-week study with rabbits, it was classified as Category 2 (nervous system, systemic toxicity).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours EC50=0.052mg/L of the crustacea (Daphnia magna) (AQUIRE (2008)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (BIOWIN), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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