GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：N,N-Dimethyldodecan-1-ylamine
CAS：112-18-5
Result：
| ID: | 1-223 |
| Classifier: | Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE） |
| Year Classified: | FY2008 |
| Reference Manual: | GHS Classification Guidance by the Japanese Government （Sep, 2008） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid |
| 6 | Flammable liquids | Not classified | - | - | - | - | Since the flash point by IUCLID(2000) is >100degC, it was classified into Not classified. |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | The test method suitable for liquid substances is not established. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | It is an organic compound not containing oxygen, fluorine or chlorine. |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid |
| 15 | Organic peroxides | Not applicable | - | - | - | - | The organic compound not including peroxy group in molecule. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
It was classified into Category 4 from LD50 value 1,450 mg/kg (SIDS (2001)) of the acute oral toxicity test (OECD TG 401, GLP) employing a mouse. |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | - | It is described that LD50 value of the dermal administration test employing a rabbit is about 5,000 mg/kg (USCh (2002)). Although this LD50 value corresponded to the U.N. GHS acute toxicity Category 5, it fell under unadopted category in Japan and was classified into "Not classified". |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable". |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 2 | Skin corrosion/irritation | Category 1 |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified into Category 1 from description of corrosion (SIDS (2001)) in the skin irritation and corrosion test with rabbits (OECD TG 404, GLP). |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
There are descriptions of "moderately irritating" in a rabbit (SIDS (2001)), "severe" irritation in the standard Draize test of a rabbit (RTECS (1997)), and "severe eye irritant" (HSDB (2003)) in humans, and all descriptions are qualitative evaluations. Since it was a skin corrosive substance, it was classified into Category 1. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | Classification is not possible since there is no data. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | From a description of negative (SIDS (2001)) in the mouse micronucleus test (OECD TG474, GLP) using Dimethylalkylamine containing 70% of this substance (in addition, 25% C12-14- and 5% C16-dimethylalkylamine) as a body cell in vivo mutagenicity test, it was classified into "Not classified". There has been a description of being negative also in the in vitro mutagenicity test employing this substance (Ames test employing bacterial cells (OECD TG471andTG472, GLP)) . |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Since there is no data, and no evaluation of major international evaluation agencies such as IARC is made, classification is not possible. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on a report that a decrease in live births, increases in stillbirths and the average loss of embryos after implantation and a decrease in average viability indicators were observed at doses which affect mother animals in a reproductive/developmental toxicity screening oral administration test (OECD TG421, GLP) in rats (SIDS (2001)), it was classified as Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | It is written in 28-day oral administration test in rats (OECD TG 407, GLP) that slight effects are found (they rub their noses against the flooring) (SIDS (2001)). Although this effect is found within the scope of the guidance value of Category 2, it is not adopted since it is not considered serious effect. Since there is no other data, classification is not possible. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 72 hours EC50=0.034mg/L of the algae (Scenedesmus) (SIDS (2005)). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 1 and there were rapid degradability (the decomposition by BOD: 74% (Existing Chemical Safety Inspections Data (1977))), since there were bio-accumulation (LogKow = 5.44 (PHYSPROP Database (2008))), it was classified into Category 1. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |