GHS Classification Result

Chemical Name：N-(1,3-Dimethylbutyl)-N'-phenyl-1,4-phenylenediamine
CAS：793-24-8

Result：
ID: 1-230
Classifier: Ministry of Economy, Trade and Industry （METI）, Ministry of the Environment （MOE）
Year Classified: FY2008
Reference Manual: GHS Classification Guidance by the Japanese Government （Sep, 2008）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid
5 Gases under pressure Not applicable - - - - Solid
6 Flammable liquids Not applicable - - - - Solid
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid
10 Pyrophoric solids Not classified - - - - Even if it contacts the normal temperature air, it does not ignite spontaneously (ignition temperature 500degC (ICSC,2006)).
11 Self-heating substances and mixtures Classification not possible - - - - The test method applicable for substances becoming liquid or gas at 140degC of test temperature has not been established.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.
13 Oxidizing liquids Not applicable - - - - Solid
14 Oxidizing solids Not applicable - - - - It is an organic compound not containing oxygen, fluorine or chlorine.
15 Organic peroxides Not applicable - - - - The organic compound not including peroxy group in molecule.
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		It was classified into Category 4 from low value of 893 mg/kg of LD50 value of 1,005 mg/kg (male) and 893 mg/kg (female) (SIDS (2004)) of the acute oral toxicity test (OECD TG 401, GLP) employing a rat.
1 Acute toxicity （Dermal） Not classified - - - - From a description of LD50 value of >7,940 mg/kg (female) (SIDS (2004)) in the dermal administration test employing rabbits, it was classified into "Not classified".
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Classification not possible due to lack of data
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Classification not possible due to lack of data
2 Skin corrosion/irritation Not classified - - - - Based on the description, " The average score of the 6 animals is less stimulative than 0.0/8.0,"(SIDS (2004)) in the 4-hour study with rabbits, it was classified into "Not classified".
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		From the description of "The average score of six rabbits after 24 hours is 20.6/110 and the redness and edema disappeared on the 5th day." in the Draize test employing rabbits (SIDS (2004)), it was classified into Category 2B.
4 Respiratory sensitization Classification not possible - - - - Classification is not possible since there is no data.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		About humans, since there are descriptions in two or more patch tests that "5 of 9 contact dermatitis patients were positive" and that "17 of 50 volunteers were positive" (both in SIDS (2004)), and from a description of "the judgement of medium sensitization in 50% at 0.05% of concentration and the judgement of very high sensitization in 90% at 0.5% of concentration" in the Maximization tests employing 20 female guinea pig (SIDS (2004)), it was classified as Category 1. It has been described that "a repeated and long-term contact may cause skin sensitization" in the paragraph of the influence of long- term or repeated exposure of ICSC (2006).
5 Germ cell mutagenicity Not classified - - - - From the description that the body cell in vivo mutagenicity tests (the micronucleus test (GLP) employing a mouse, chromosome aberration test using a rat (GLP)) are "negative" (SIDS (2004)), it was classified into "Not classified".
6 Carcinogenicity Classification not possible - - - - Since no evaluation by major international evaluation agencies is made and there is a description that "there is no research example with sufficient evidence" (SIDS (2004)), classification is not possible.
7 Reproductive toxicity Not classified - - - - There is a description in the 3 generation mixed food administration study with female and male rats as follows, "Although body weight reduction was observed in the medium dose group and high dose group from E0 generation to F3 generation (75mg/kg), no effect was found on reproductive functions and activities and there was no histopathological change. "The number of live pups was same in all generations" (SIDS (2004). Moreover, there is a description in the reproductive/developmental toxicity screening study using rats (OECD TG 421, GLP)as follows, "There was no effect on denital functions and no effect was observed among child animals at the dose level where liver hypertrophy and vacuolar degeneration were recognized among females and males" (The Ministry of Health, Labour and Welfare Report (Access on September 2008). For the reasons stated above, it was classified into "Not classified".
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In the acute oral toxicity test employing rats (OECD TG 401, GLP) "Abdominal position, locomotor activity reduction, as for the fall of a posture and a locomotor activity, hind limb weakness, exhaustion of a hind foot, gait abnormality, etc., tend to recover. There is a description of "White hyperplasia part is observed in proventriculus mucosa."(the Health, Labor and Welfare Ministry reports (Access on September 2008), SIDS (2004))It has been described as "no effect" (SIDS (2004)) in the acute dermal administration test employing rabbits. Although the influence on the stomach in the oral administration test is seen within the range of the guidance value of Category 2, it was judged as a specific condition due to the forced oral administration and it is not adopted. As mentioned above, it was classified into Category 3 (Narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It is written in 28-day repeated oral administration test in rats (GLP) that"there were adiposis of periportal hepatocytes, increase in liver weight, and anemia tendency, however, the result showing abnormality of liver was not obtained by biochemical exam of blood (Ministry of Health, Labour and Welfare reports (Access on September 2008), SIDS (2004)), and "hemolytic anemia" was described in 13-week repeated oral administration test in rats (GLP) (SIDS (2004)), and effects on blood systems were found within the scope of the guidance value of Category 2. Therefore, it was classified into Category 2 (blood systems).
10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=0.028mg/L of the fish (Oryzias Latipes) (SIDS (2005)).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Since acute toxicity was Category 1 and there were no rapid degradability (not readily degradable, the decomposition by BOD: 2%(Existing Chemical Safety Inspections Data (1995))), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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